Tunicamycin CAS: 11089-65-9
MF: C38H62N4O16 (Tun B)
MW: 840.0 (Avg.)

Tunicamycin (CAS 11089-65-9)

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Tunicamycin is rated 4.5 out of 5 by 2.
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別名: Tunicamycin also known as nucleoside antibiotic
アプリケーション: Tunicamycin is a competitive cell cycle inhibitor exhibiting antiungal properties and is widely used in the study of glycoprotein synthesis
CAS 番号: 11089-65-9
Purity: ≥99% (total complex)
Molecular Weight: 840.0 (Avg.)
Molecular Formula: C38H62N4O16 (Tun B)
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).

Tunicamycin is a mixture of tunicamycins A, B, C and D and has been widely used in the study of glycoprotein synthesis in various biological systems. Tunicamycin inhibits GlcNAc phosphotransferase (GPT) and inhibts the formation of N-glycosidic linkages in glycoprotein sunthesis. Tunicamycin has also been reported to have a dose-dependent inhibition of DNA synthesis, inhibit protein glycosylation, suppression of the S phase and to also arrest the cell cycle in late G1. As a member of a family of antibiotics produced by Streptomyces lysosuperficus, tunicamycin is noted to be active in vitro against gram-positive bacteria, fungi, yeasts and viruses. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Through this mechanism, it has been postulated to arrest cell cycling as a competitive inhibitor of glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins which thereby affect the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.


参考文献

1. Duksin, D., et al. 1982. J. Biol. Chem. 257: 3105-3109. PMID: 7061468

2. Langan, T.J. and Slater, M.C. 1991. J. Cell Physiol. 149: 284-292. PMID: 1748720

3: Ishii, S. and Volpe, J.J. 1987. J. Neurochem 49: 1606-1612. PMID: 3668542

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in water (partly miscible), alkaline water, pyridine, hot methanol, DMSO (>10 mg/ml), ethanol (5 mg/ml), butanol (slightly), and DMF. Insoluble in acetone, ethyl acetate, chloroform, benzene, and acidic water.
保存方法 :
Store at room temperature
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
YO7980200
Merck Index :
14: 9819
MDL Number :
MFCD00065709
Beilstein Registry :
6888090

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Tunicamycin (CAS 11089-65-9)  参考文献

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引用 1 to 10 of 45 合計

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PMID: # 25903460  Kim, AY. et al. 2015. BMC Genomics. 16: 338.

PMID: # 26040720  Khaminets, A. et al. 2015. Nature. 522: 354-8.

PMID: # 25824232  Li, R. et al. 2015. Antimicrob. Agents Chemother. 59: 3460-8.

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