Brefeldin A CAS: 20350-15-6
MF: C16H24O4
MW: 280.36
A fungal metabolite exhibiting a wide range of antibiotic activities and activator of caspase-3.

Brefeldin A (CAS 20350-15-6)

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同義語 γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin
アプリケーション: A fungal metabolite exhibiting a wide range of antibiotic activities and activator of caspase-3
CAS 番号: 20350-15-6
Purity: ≥98%
Molecular Weight: 280.36
Molecular Formula: C16H24O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Brefeldin A is a fungal metabolite that disrupts the structure and function of the Golgi apparatus. The compound induces the Golgi proteins to redistribute into the ER and blocks the secretion from the Golgi apparatus. Studies show that it blocks the GTP-dependent interaction of ARF with the Golgi membrane, thus inhibiting the assembly of coatomer onto the membrane. Research shows that Brefeldin A can induce apoptosis in Neuroendocrine tumor cells by activating caspase-3, and inhibits cell growth by targeting the cell cycle in prostate cancer cells. Brefeldin A is an inhibitor of ARF.


参考文献

1. Lippincott-Schwartz, J., et al. 1990. Cell. 60: 821-836. PMID: 2178778
2. Orci, L, et al. 1991. Cell. 64: 1183-1195. PMID: 2004424
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4. Donaldson, J.G., et al. 1991. Science. 254: 1197-1199. PMID: 1957170
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9. Rajamahanty, S., et al. 2010. J. Biomed. Sci. 17: 5. PMID: 20102617

Physical State :
Solid
Derived From :
Eupenicillum sp. UN88
Solubility :
Soluble in water (Partly miscible), methanol (10 mg/mL), ethanol (5 mg/mL), DMSO (20 mg/mL), acetone, and ethyl acetate (1 mg/mL).
保存方法 :
Store at -20° C
Melting Point :
200° C
Boiling Point :
~492.7° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.51
Optical Activity :
α20/D 96°±2° in methanol; α20/D 93°, c = 2 in methanol
IC50 :
B-cell specific antigen receptor-induced NF-kB activation: IC50 = 420 nM (HEK-293T cell line)
pK Values :
pKa: 12.92
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
GY8410000
PubChem CID :
5287620
Merck Index :
14: 1369
MDL Number :
MFCD00083258
EC Number :
247-104-4
Beilstein Registry :
25191

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Brefeldin A  参考文献

See how others have used Brefeldin A. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 29295953  Shim, SM. et al. 2018. Sci Signal. 11:

PMID: # 27818291  Wanka, L. et al. 2017. Cell. Signal. 29: 233-239.

PMID: # 27121042  Schumacher, MM. et al. 2016. J. Lipid Res. 57: 1286-99.

PMID: # 24943726  Vogelzang, A. et al. 2014. J. Infect. Dis. 210: 1928-37.

PMID: # 25319670  Chang, FY. et al. 2014. Biochemistry. 53: 7123-31.

PMID: # 22998223  Luo, Y. et al. 2013. Traffic. 14: 97-106.

PMID: # 22767227  Cai, Q. et al. 2012. FASEB J. 26: 3306-20.

PMID: # 22275357  Tachikawa, M. et al. 2012. The Journal of biological chemistry. 287: 8398-406.

PMID: # 16467202  Zernecke A, et al. 2006. Blood. 107(11): 4240-4243.

PMID: # 26942056  Gao, J.|Duan, Z.|Zhang, L.|Huang, X.|Long, L.|Tu, J.|Liang, H.|Zhang, Y.|Shen, T.|Lu, F.| et al. Oncoimmunology. 5: e1048061.

Citations 1 to 10 of 10 total
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