ATF-6α Activators
ATF-6α activators represent a diverse group of chemical compounds that directly enhance its functional activity or influence signaling events leading to activation. ATF-6α plays a crucial role in regulating the unfolded protein response within the endoplasmic reticulum (ER). The selected compounds target specific pathways or processes, contributing to increased ATF-6α activity. One group of activators includes 4-Phenylbutyric Acid (4-PBA) and Guanabenz, which enhance ATF-6α activity by modulating ER stress response. These compounds facilitate ATF-6α-mediated unfolded protein response, suggesting their potential in modulating cellular adaptation to proteotoxic stress. Salubrinal and ISRIB modulate ATF-6α activity by influencing eIF2α phosphorylation, impacting protein translation and the unfolded protein response. These compounds indicate a role for ATF-6α in maintaining protein homeostasis during ER stress.
Ceapin-A and Ceapin-C enhance ATF-6α function by preventing its proteasomal degradation, stabilizing ATF-6α and leading to increased nuclear translocation. These compounds contribute to the regulation of ER stress response, sustaining cellular protein homeostasis. STF-083010 and CCT020312 influence ATF-6α activation by preventing eIF2α phosphorylation, promoting ATF-6α-mediated unfolded protein response. These compounds indicate a role for ATF-6α in cellular adaptation to ER stress and maintaining protein homeostasis. Luteolin and Compound 147 modulate ATF-6α activity by influencing its proteolytic processing and subsequent activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Phenylbutyric acid | 1821-12-1 | sc-232961 sc-232961A sc-232961B | 25 g 100 g 500 g | $53.00 $136.00 $418.00 | 10 | |
4-PBA enhances ATF-6α activity by promoting protein folding in the endoplasmic reticulum (ER). It alleviates ER stress, facilitating ATF-6α activation and subsequent regulation of unfolded protein response, contributing to cellular homeostasis. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal enhances ATF-6α function by inhibiting eIF2α dephosphorylation, intensifying ER stress response. This compound augments ATF-6α-mediated unfolded protein response, suggesting its potential in modulating cellular adaptation to proteotoxic stress. | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | $300.00 | 1 | |
ISRIB enhances ATF-6α activity by preventing eIF2α phosphorylation, promoting protein translation and ATF-6α-mediated unfolded protein response. This compound influences cellular adaptation to ER stress, indicating its role in maintaining protein homeostasis. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $102.00 $468.00 $832.00 $4162.00 $7283.00 | 2 | |
Guanabenz enhances ATF-6α function by inhibiting eIF2α dephosphorylation, intensifying ER stress response. This compound augments ATF-6α-mediated unfolded protein response, suggesting its potential in modulating cellular adaptation to proteotoxic stress. | ||||||
2-Aminopurine | 452-06-2 | sc-287828 sc-287828A | 100 mg 250 mg | $118.00 $185.00 | ||
2-Aminopurine enhances ATF-6α activity by inhibiting its proteasomal degradation. This compound stabilizes ATF-6α, leading to increased nuclear translocation and subsequent regulation of ER stress response, indicating its role in sustaining cellular protein homeostasis. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin enhances ATF-6α function by modulating its proteolytic processing and subsequent activation. This compound facilitates ATF-6α-mediated unfolded protein response, suggesting its involvement in cellular mechanisms responding to endoplasmic reticulum stress. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-MA enhances ATF-6α activity by modulating its proteolytic processing and subsequent activation. This compound facilitates ATF-6α-mediated unfolded protein response, suggesting its involvement in cellular mechanisms responding to endoplasmic reticulum stress. | ||||||