ATF-1 Inhibitors
ATF-1 (Activating Transcription Factor 1) inhibitors constitute a chemical class of compounds that are integral to the field of molecular biology and gene regulation research. ATF-1 is a transcription factor that belongs to the larger ATF/cAMP response element-binding protein (CREB) family of proteins. It plays a central role in gene expression regulation by binding to specific DNA sequences known as cAMP response elements (CREs) within the promoter regions of target genes. ATF-1 is particularly recognized for its involvement in cellular responses to various stressors and stimuli, including environmental stresses, growth factors, and hormonal signals.
ATF-1 inhibitors are designed to interfere with the transcriptional activity of ATF-1, often by disrupting its binding to CRE sequences or modulating its interactions with co-regulatory proteins. By inhibiting ATF-1, these compounds can influence the expression of genes that are under the transcriptional control of ATF-1, offering researchers a powerful tool to dissect the molecular mechanisms underlying cellular responses to different stimuli. This enables scientists to elucidate the precise roles of ATF-1 in various cellular processes, including stress responses, cell proliferation, and differentiation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
Inhibits PKA, which is involved in ATF-1 activation via phosphorylation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits p38 MAP kinase, potentially affecting ATF-1 activation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, a kinase that can phosphorylate and activate ATF-1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K, affecting ATF-1 activation indirectly through stress pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Another MEK inhibitor, similar in function to U0126, potentially affecting ATF-1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor, might affect ATF-1 expression or activation indirectly. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, which can influence ATF-1 activity under certain stress conditions. | ||||||