Astrotactin 2 Inhibitors
Chemical inhibitors of Astrotactin 2 can exert their inhibitory effects through various mechanisms that ultimately disrupt cellular structures and processes essential for the protein's function. Alsterpaullone, as a cyclin-dependent kinase inhibitor, can induce cell cycle arrest, which may prevent the proper trafficking and function of Astrotactin 2 by stalling cellular dynamics and division. Similarly, Latrunculin A and Cytochalasin D both target the actin cytoskeleton, albeit through different mechanisms-Latrunculin A by sequestering actin monomers and Cytochalasin D by capping the growing ends of actin filaments. These disruptions can impede the actin-based motility processes that are essential for Astrotactin 2's role in neuronal migration. Blebbistatin and ML-7 further contribute to this inhibition by targeting myosin II ATPase and myosin light chain kinase, respectively, both of which are critical for cellular contractility and movement, processes in which Astrotactin 2 is likely involved.
In addition to actin, microtubule dynamics are also crucial for neuronal migration and Astrotactin 2 function. Colchicine, Nocodazole, and Paclitaxel (Taxol) are three chemicals that perturb microtubule stability, with Colchicine and Nocodazole disrupting microtubule polymerization and Paclitaxel overly stabilizing them, preventing the dynamic reorganization required for Astrotactin 2 to function effectively in neuron migration. Y-27632, a ROCK inhibitor, and Gö 6983, a protein kinase C inhibitor, modulate signaling pathways that regulate actin cytoskeleton remodeling, further contributing to the inhibition of Astrotactin 2 by altering the cellular environment necessary for its activity. Jasplakinolide's stabilization of actin filaments can inhibit Astrotactin 2 indirectly by affecting the actin dynamics required for neuronal migration. Lastly, CK-636 inhibits the Arp2/3 complex, which is integral to actin filament branching and, consequently, dendritic spine development. This inhibition can impede the proper localization and function of Astrotactin 2, as it is a protein implicated in the precise cellular processes that require dynamic actin and microtubule networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a known inhibitor of cyclin-dependent kinases. Inhibition of these kinases can lead to cell cycle arrest, which in turn may prevent the trafficking of Astrotactin 2 to the plasma membrane due to reduced cellular dynamics and division. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A disrupts microfilament organization by binding to actin monomers. Astrotactin 2, involved in neuronal migration, may rely on actin dynamics, and the disruption of actin polymerization can inhibit its function. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin is an inhibitor of myosin II ATPase activity. By disrupting myosin function, it can impair cellular processes that rely on myosin, including the potential movement or localization of Astrotactin 2 within neurons. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor that can disrupt signaling pathways involving actin cytoskeleton remodeling. As Astrotactin 2 is implicated in neuron migration, inhibition of ROCK may impair the cytoskeletal rearrangements necessary for its function. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization into microtubules. Astrotactin 2's role in neuronal movement could be dependent on intact microtubules, and their destabilization can inhibit Astrotactin 2 function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and can inhibit their dynamics. As dynamic microtubules are essential for neuronal migration, the presence of paclitaxel can impede processes that depend on microtubule reorganization, such as Astrotactin 2 function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that can disrupt microtubule networks. By affecting microtubule dynamics, nocodazole can inhibit cellular processes that rely on microtubule-based transport, potentially inhibiting Astrotactin 2 function. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK), which is involved in myosin regulatory pathways. By inhibiting MLCK, ML-7 can affect cellular contractility and thus may inhibit Astrotactin 2-related neuron migration processes. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D blocks actin polymerization, disrupting cytoskeletal dynamics. This can inhibit neuronal processes that depend on the actin cytoskeleton, potentially affecting the function of Astrotactin 2. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Gö 6983 is a broad-spectrum protein kinase C (PKC) inhibitor. PKC is involved in various cellular signaling pathways, including those that regulate cytoskeletal dynamics, which are crucial for the function of Astrotactin 2 in neuron migration. | ||||||