ASPP1 Activators
ASPP1 Activators comprise a group of chemical compounds that, through various biochemical mechanisms, indirectly augment the functional activity of ASPP1. Forskolin, by elevating intracellular cAMP levels, indirectly enhances ASPP1's role in apoptosis by activating PKA, which may phosphorylate substrates that influence ASPP1's activity. Staurosporine, through its inhibition of protein kinases that negatively regulate ASPP1, indirectly promotes its pro-apoptotic functions. Resveratrol activates SIRT1, leading to the enhanced activity of p53, a protein regulated by ASPP1, thus indirectly promoting ASPP1's role in apoptosis. LY294002 and Curcumin bring about changes in the cell survival pathways by inhibiting PI3K and NF-κB, respectively, which can lead to an enhancement of ASPP1's tumor suppressor functions. Spermidine further supports ASPP1 activity by inducing autophagy, a process that can stabilize and enhance ASPP1. Celecoxib and Rapamycin, through COX-2 inhibition and mTOR inhibition, respectively, suppress survival signals, thereby potentially enhancing ASPP1-mediated apoptotic pathways.
In addition to these, Z-VAD-FMK, despite being a pan-caspase inhibitor, can indirectly increase ASPP1 activity by leading to a buildup and subsequent release of caspase activity, which is an environment where ASPP1's role may be heightened. Sulforaphane activates Nrf2, enhancing ASPP1's function in oxidative stress-related apoptosis. Quercetin and PD98059, by inhibiting PI3K/STAT3 and MEK/ERK respectively, reduce pro-survival signaling, thereby creating a cellular context that favors ASPP1's apoptotic function. Collectively, these ASPP1 Activators, through their influence on specific pathways and molecules, facilitate the enhancement of ASPP1-mediated functions without the need for upregulating its expression or direct activation, maintaining cellular homeostasis and promoting apoptotic processes that are essential to tumor suppression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate and enhance the functional activity of ASPP1, promoting its role in apoptosis and tumor suppression. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases. It can indirectly enhance ASPP1 activity by inhibiting kinases that negatively regulate ASPP1, thus facilitating its pro-apoptotic functions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which can deacetylate and enhance the activity of various proteins, including p53. ASPP1 is a known regulator of p53, and by enhancing p53's activity, Resveratrol may indirectly increase the functional activity of ASPP1 in apoptosis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. By inhibiting PI3K, it can decrease AKT phosphorylation and activity, which may enhance ASPP1's tumor suppressor functions, as AKT can negatively regulate proteins involved in apoptosis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to modulate multiple signaling pathways, including inhibition of NF-κB. By inhibiting NF-κB, Curcumin can enhance ASPP1 mediated apoptotic pathways, as NF-κB can suppress apoptosis. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine induces autophagy through inhibition of the acetyltransferase EP300. Autophagy has been associated with the degradation of damaged proteins and organelles, potentially leading to the stabilization and enhanced activity of ASPP1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which is a central regulator of cell growth and survival. Inhibition of mTOR by Rapamycin could enhance ASPP1's role in promoting apoptosis by reducing signals that oppose this pathway. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $75.00 | 256 | |
Z-VAD-FMK is a pan-caspase inhibitor that can paradoxically enhance the activity of ASPP1 by causing an accumulation of caspases, which, once the inhibitor is removed, can lead to a burst of apoptotic activity where ASPP1 may play a role. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that has been shown to inhibit PI3K and STAT3, which are involved in survival and proliferation pathways. This inhibition can enhance ASPP1's apoptotic functions by reducing pro-survival signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is an inhibitor of MEK, which indirectly reduces ERK activation. Reduced ERK activity can lead to enhanced ASPP1 function by decreasing proliferative and survival signals that counteract apoptotic pathways. | ||||||