ASPG Activators
ASPG, or asparaginase, is a crucial enzyme in the metabolism of amino acids, specifically in the conversion of L-asparagine into aspartic acid and ammonia. This conversion is a key step in nitrogen metabolism and is influenced by the levels of L-asparagine. The efficiency of ASPG can be further affected by the concentration of its reaction products, aspartic acid and ammonia, which may enhance the enzyme's activity in certain conditions where an increase in product concentration signals a need for more enzyme activity. Additionally, certain hormones known to regulate the expression of metabolic enzymes could potentially lead to an upsurge in ASPG activity by increasing its expression levels.
Compounds that affect the cellular requirement for asparagine can also indirectly modulate the activity of ASPG. For example, conditions that increase the cell's demand for asparagine may lead to a secondary rise in ASPG activity to meet this need. Cellular stress and changes in nucleotide metabolism, which are associated with an increased need for asparagine, could also lead to an upregulated ASPG function. Moreover, the presence of metabolic intermediates that are part of asparagine synthesis and utilization pathways might contribute to a regulatory feedback loop, influencing the activity of ASPG. These intermediates could signal the cellular metabolic status to the enzyme, potentially enhancing its catalytic response to fluctuations in asparagine levels.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A glucocorticoid that can induce the expression of genes encoding for enzymes involved in amino acid metabolism, including ASPG, enhancing its enzymatic activity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
As an antimetabolite, it can increase the demand for asparagine by cells, thereby potentially increasing the activity of ASPG to compensate for the depleted asparagine levels. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
A nucleoside metabolic inhibitor that can lead to increased ASPG activity as it indirectly causes cells to upregulate nucleotide synthesis pathways that are sensitive to asparagine levels. | ||||||
L-Aspartic acid | 56-84-8 | sc-472377A sc-472377 sc-472377B | 25 g 100 g 500 g | $40.00 $33.00 $48.00 | ||
The product of ASPG enzymatic activity on L-asparagine, which can feedback to enhance the protein's function under certain cellular conditions where product-induced activation occurs. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Can induce the expression of enzymes involved in amino acid metabolism, potentially increasing the activity of ASPG. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $72.00 $104.00 | ||
Can increase the need for asparagine synthesis, indirectly triggering increased ASPG activity in asparagine catabolism. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $131.00 | ||
A xanthine oxidase inhibitor that can lead to increased purine synthesis and hence, a higher requirement for asparagine, indirectly increasing ASPG activity. | ||||||
L-Glutamine | 56-85-9 | sc-391013 sc-391013C sc-391013A sc-391013D sc-391013B | 100 g 250 g 1 kg 5 kg 10 kg | $37.00 $47.00 $99.00 $379.00 $733.00 | 2 | |
An amino acid that participates in nitrogen metabolism. It could increase the demand for asparagine synthesis, indirectly enhancing ASPG activity. | ||||||
L-Serine | 56-45-1 | sc-397670 sc-397670A sc-397670B sc-397670C sc-397670D | 1 g 100 g 1 kg 5 kg 10 kg | $20.00 $133.00 $546.00 $1224.00 $2040.00 | ||
An amino acid that can be converted to aspartic acid, which can then provide feedback to ASPG, leading to an increase in its functional activity under specific metabolic conditions. | ||||||