Asp1 Inhibitors
Chemical inhibitors of Asp1 can function through a variety of mechanisms to impede its activity. Staurosporine, a broad-spectrum protein kinase inhibitor, targets the ATP-binding site essential for kinase activity, which prevents the phosphorylation and activation of Asp1. Similarly, palbociclib operates by selectively inhibiting cyclin-dependent kinases, potentially affecting the phosphorylation state and thus the regulation of Asp1. Dasatinib, with its focus on Src family kinases, can impede the tyrosine phosphorylation that is necessary for Asp1 activation. Furthermore, LY294002, as a PI3K inhibitor, can disrupt the PI3K pathway and thereby affect downstream targets, including Asp1.
Continuing with this theme, U0126 and PD98059, both inhibitors of MEK, can disrupt the MAPK/ERK pathway, which may be upstream of Asp1, leading to reduced functional activity of Asp1 due to lack of necessary phosphorylation. SB203580 specifically inhibits p38 MAPK, and by doing so, can suppress the activation of Asp1 if it is indeed a part of the p38 MAPK signaling pathway. In a similar vein, SP600125 acts as an inhibitor of JNK, another kinase that can phosphorylate and activate Asp1, while Rapamycin inhibits mTOR, which can have downstream effects on the activity of Asp1. Wortmannin, another PI3K inhibitor, can also lead to the functional inhibition of Asp1 by blocking the PI3K/Akt pathway. Imatinib, although it primarily targets other kinases such as BCR-ABL, c-Kit, and PDGF receptors, can also inhibit the phosphorylation and subsequent activation of Asp1. Lastly, MG132, while not a direct inhibitor, can affect the function of Asp1 by increasing the levels of ubiquitinated proteins, which can bind to and sequester Asp1, thereby preventing it from engaging in its normal biological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. Asp1 is known to be involved in phosphorylation processes; staurosporine inhibits this activity by preventing ATP binding and kinase activation, leading to the inhibition of Asp1. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a selective inhibitor of cyclin-dependent kinases. As Asp1 may be regulated by cell cycle-dependent phosphorylation, palbociclib can inhibit Asp1 by hindering the kinase activity that would typically phosphorylate Asp1. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor. Asp1 activity can be regulated by Src family kinases through tyrosine phosphorylation; dasatinib inhibits these kinases, thereby inhibiting the subsequent activation of Asp1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. Asp1, involved in signaling pathways regulated by PI3K, can be functionally inhibited when LY294002 suppresses the PI3K pathway, leading to inactivation of downstream targets of Asp1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, which is upstream in the MAPK/ERK pathway. Asp1, as a part of this pathway, is functionally inhibited when U0126 prevents the activation of MEK, thereby reducing the pathway's activity and the function of Asp1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibition of p38 MAPK can lead to the functional inhibition of Asp1 if Asp1 is involved in the p38 MAPK signaling pathway by preventing the phosphorylation steps that activate Asp1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. Asp1, which may function downstream of mTOR signaling, is inhibited by rapamycin through the suppression of mTOR-dependent signaling pathways that would otherwise lead to Asp1 activation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK. Asp1, if functioning as part of the JNK signaling pathway, is inhibited by SP600125 through the blockade of JNK-mediated phosphorylation events that are necessary for Asp1 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which acts upstream of ERK in the MAPK pathway. By inhibiting MEK, PD98059 indirectly inhibits the functional activity of Asp1 by blocking the necessary phosphorylation signals that activate Asp1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. Inhibition of PI3K can lead to functional inhibition of Asp1 by halting the PI3K/Akt pathway, which is essential for the full activation of Asp1. | ||||||