Asp1 Activators
Asp1, a pivotal protein in cellular signaling, is influenced by a spectrum of chemical activators that modulate various biochemical pathways, thereby enhancing its activity. Adenosine Triphosphate (ATP) plays a fundamental role in energizing Asp1's structural changes for activation, while Calcium Chloride and Magnesium Sulfate provide essential ions that stabilize and enhance Asp1's catalytic function. This ion-mediated enhancement is critical, as calcium and magnesium ions are directly involved in the regulation of Asp1's activity. Sodium Orthovanadate and Epigallocatechin Gallate exert their effects by modulating protein phosphorylation levels; the former inhibits protein tyrosine phosphatases leading to increased phosphorylation, while the latter inhibits competing kinase pathways, resulting in an indirect enhancement of Asp1's activity. Furthermore, Forskolin, by elevating cAMP levels, and Nitric Oxide Donor (SNAP), by increasing cGMP levels, regulate secondary messenger systems that profoundly influence Asp1 activity. These compounds demonstrate how altering intracellular messenger levels can indirectly enhance the function of proteins like Asp1 through complex signaling cascades.
In addition to these mechanisms, Asp1's activity is also modulated by compounds affecting lipid signaling and protein phosphorylation states. Lysophosphatidic Acid, by engaging with G-protein coupled receptors, influences pathways that converge on Asp1, enhancing its activity through lipid-derived second messengers. Phorbol 12-Myristate 13-Acetate (PMA) serves as a potent activator of Protein Kinase C (PKC), which then modifies the phosphorylation landscape in a way that favors Asp1 activation. Similarly, U0126, by inhibiting the MEK component of the MAPK pathway, shifts cellular signaling in a manner that potentially enhances Asp1-related pathways. Okadaic Acid further contributes by inhibiting phosphatases PP1 and PP2A, increasing phosphorylation within the cell and indirectly affecting Asp1 activity. Lastly, Zinc Sulfate is crucial as zinc ions are not only structural stabilizers but also integral to the catalytic efficiency of Asp1. Collectively, these activators intricately and indirectly enhance Asp1's functional activity, showcasing the complexity and interconnectivity of cellular signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium Chloride elevates intracellular calcium levels. Asp1 is sensitive to calcium fluctuations, which trigger conformational changes, enhancing its catalytic activity. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $45.00 $68.00 $160.00 $240.00 $410.00 | 3 | |
Magnesium Sulfate provides magnesium ions essential for Asp1's catalytic function. Magnesium stabilizes the structure of Asp1 and participates in substrate binding, thus enhancing its enzymatic activity. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium Orthovanadate inhibits protein tyrosine phosphatases. This inhibition leads to an increase in phosphorylation levels, indirectly enhancing Asp1 activity through altered cellular signaling dynamics. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP indirectly enhances Asp1 activity by modulating the PKA signaling pathway, which interacts with Asp1-related pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate, a kinase inhibitor, indirectly enhances Asp1 by inhibiting competing kinase pathways, leading to a relative increase in Asp1-mediated signaling. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
Lysophosphatidic Acid interacts with G-protein coupled receptors, influencing downstream signaling that enhances Asp1 activity through second messenger systems like IP3 and DAG. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Protein Kinase C (PKC), which indirectly influences Asp1 activity by modifying the phosphorylation state of proteins within Asp1-related signaling pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK, a part of the MAPK pathway. Inhibition of MEK shifts the cellular signaling balance, potentially enhancing pathways that lead to Asp1 activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within cells. This state can indirectly enhance Asp1 activity by altering its interaction with phosphorylated substrates. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Sulfate provides zinc ions, which are critical cofactors for Asp1. Zinc stabilizes Asp1's structure and is essential for its catalytic function, thereby enhancing its activity. | ||||||