ASIC1 Activators
ASIC1, short for Acid-Sensing Ion Channel 1, is an integral component of the family of proton-gated cation channels. These channels are sensitive to extracellular pH and are predominantly expressed in the nervous system, especially in the brain and peripheral sensory neurons. Activation of ASIC1 is primarily initiated by a decrease in extracellular pH, rendering them as acid-sensing entities. Therefore, any compound or agent that facilitates or heightens the activity of these channels can be referred to as an "ASIC1 activator".
ASIC1 activators, as the name suggests, are a class of chemical compounds that promote or enhance the activation of ASIC1 channels. Their mechanism of action often involves mimicking the effects of a reduced extracellular pH or altering the channel configuration to favor its open state, thereby allowing ions to pass through. Many of these activators have diverse chemical structures, spanning from small organic molecules to more complex derivatives. Understanding the intricacies of these activators and how they interact with the ASIC1 channels at the molecular level is crucial for researchers aiming to delve deep into the physiological and cellular roles of acid-sensing channels. A nuanced appreciation of these interactions can pave the way for targeted investigations into various physiological processes, such as mechanosensation, learning and memory, and nociception, all of which are believed to be influenced by ASIC1 channel activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, has been reported to modulate the expression of various genes. It may influence the upregulation of ASIC1 expression as part of its role in neuronal differentiation and development. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound found in turmeric, may alter ASIC1 expression as part of its known anti-inflammatory and neuroprotective effects, potentially modulating neuronal excitability. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, found in the plant Coleus forskohlii, activates adenylate cyclase. This may subsequently increase cAMP levels, potentially leading to the upregulation of ASIC1 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, may enhance ASIC1 expression as part of its neuroprotective effects, potentially influencing synaptic function and plasticity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, found in grapes and red wine, may modulate ASIC1 expression through its antioxidant and anti-inflammatory properties, possibly influencing neuronal function. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane can upregulate ASIC1 expression due to its ability to activate Nrf2, which regulates the expression of various genes involved in neuroprotection. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may modulate the expression of ASIC1 as part of its neuroprotective effects, potentially influencing neuronal responses to external stimuli. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a corticosteroid, could modulate ASIC1 expression as it's known to regulate a wide array of genes, potentially impacting neuronal excitability. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide, as an oxidative agent, may stimulate the expression of ASIC1 as a response to oxidative stress, potentially influencing neuronal adaptation. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone, a PPARγ agonist, might influence ASIC1 expression due to its role in modulating inflammation and cellular energy homeostasis. | ||||||