ASCL5 Inhibitors
The chemical class of ASCL5 inhibitors is characterized by compounds targeting crucial cellular pathways intricately associated with neurogenesis. Among these is the Notch signaling pathway, vital in deciding cell fate during neurogenesis, targeted by DAPT. An association between ASCL5 and the Notch pathway suggests that DAPT can modulate ASCL5 function. SU5402 acts as an inhibitor to the FGF receptor, another pivotal element in neurogenesis. Given the modulation of Achaete-scute family members by FGF signaling, SU5402 can indirectly affect ASCL5. CHIR99021, a GSK-3β inhibitor, brings forth the canonical Wnt/β-catenin signaling's importance in neurogenesis, thus hinting at a probable influence on ASCL5.
Retinoic acid, a well-known regulator of neural differentiation, stands out as a modulator of transcription factors, including ASCL5. Autophagy, a cellular recycling mechanism with a role in neural differentiation, can be enhanced by SMER28, offering another avenue for ASCL5 modulation. BMP signaling, a vital determinant in neural patterning, is inhibited by LDN-193189, suggesting another possible interaction point with ASCL5. The breadth of the cellular landscape that ASCL5 operates in is evident from the inclusion of inhibitors targeting p53, Hedgehog signaling, HDACs, epigenetic modifiers, mitochondrial functions, and DNA helicases.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
Notch signaling pathway inhibitor. Given that Achaete-scute family members can be regulated by Notch signaling during neurogenesis, DAPT can indirectly inhibit ASCL5's function. | ||||||
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $63.00 $98.00 | 36 | |
FGF receptor inhibitor. FGF signaling can modulate neurogenesis and thus affect ASCL5 activity indirectly. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
GSK-3β inhibitor, involved in canonical Wnt/β-catenin signaling, a pathway critical in neurogenesis. This could modulate ASCL5 if it's influenced by this pathway. | ||||||
SMER28 | 307538-42-7 | sc-222320 | 10 mg | $173.00 | ||
Enhancer of autophagy; Autophagy plays a role in neural differentiation and can influence ASCL5 indirectly. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
BMP signaling inhibitor; BMP signaling plays a role in neural patterning and differentiation, potentially modulating ASCL5 activity. | ||||||
Pifithrin-α hydrobromide | 63208-82-2 | sc-45050 sc-45050A | 5 mg 25 mg | $120.00 $300.00 | 36 | |
p53 inhibitor; p53 can be involved in neurogenesis and neuronal survival, thus influencing ASCL5 indirectly. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Hedgehog signaling pathway inhibitor; This pathway is crucial for certain aspects of neurogenesis and can indirectly influence ASCL5. | ||||||
M 344 | 251456-60-7 | sc-203124 sc-203124A | 1 mg 5 mg | $109.00 $322.00 | 8 | |
HDAC inhibitor; HDACs regulate gene expression and are involved in neurogenesis, which can impact ASCL5 activity. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
Inhibitor of G9a histone methyltransferase; Epigenetic modifications play a role in neural differentiation, influencing ASCL5 indirectly. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Inhibitor of mitochondrial ATP synthase; Mitochondrial function is critical in neurogenesis, which can indirectly modulate ASCL5 activity. | ||||||