ASB-1 Inhibitors
ASB-1 inhibitors work by influencing the ubiquitin-proteasome system and related protein degradation pathways. This is because ASB-1 is an E3 ubiquitin ligase, and its main function is to mark proteins for degradation via the proteasome. Bortezomib, MG-132, Epoxomicin, and Lactacystin are all proteasome inhibitors. They inhibit the proteasome, preventing the degradation of proteins that have been marked by ubiquitination, which disrupts the role of ASB-1 in protein turnover. Eeyarestatin I is an inhibitor of the endoplasmic reticulum-associated degradation (ERAD) pathway, another protein degradation pathway. By inhibiting ERAD, Eeyarestatin I can disrupt the balance between protein synthesis and degradation, which can affect the function of ASB-1The ubiquitin-proteasome system is a key pathway that involves ASB-1, and the inhibitors of this system can effectively impede the ASB-1 protein function. For example, Ubistatins A and B inhibit the binding of ubiquitinated proteins to the proteasome, which in turn disrupts protein degradation and inhibits the function of E3 ubiquitin ligases like ASB-1. This mechanism is also shared by PR-619, a broad-spectrum deubiquitinase inhibitor, which disrupts the balance of ubiquitination and deubiquitination, key processes for the function of ASB-1.
The function of ASB-1 can also be influenced by chemicals that impact related pathways or processes. For instance, PYR-41, an irreversible inhibitor of ubiquitin-activating enzyme E1, influences the first step of the ubiquitination process and its inhibition can affect the function of E3 ubiquitin ligases like ASB-1. Similarly, MLN4924, a NEDD8-activating enzyme inhibitor, could affect ASB-1 function as NEDD8 modifies cullin proteins, which are part of the Cullin-RING E3 ubiquitin ligases that ASB-1 is a member of. Chloroquine, by disrupting lysosomal function, can affect the degradation of proteins marked by ASB-1. Auranofin, a Thioredoxin reductase inhibitor, can lead to oxidative stress, affecting the function of many proteins, including ASB-1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $114.00 $203.00 $354.00 $697.00 $1363.00 $5836.00 | 12 | |
Eeyarestatin I is an inhibitor of the endoplasmic reticulum-associated degradation (ERAD) pathway, which is also involved in protein degradation. By inhibiting ERAD, Eeyarestatin I can disrupt the balance between protein synthesis and degradation, potentially affecting the function of ASB-1. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Leupeptin is a protease inhibitor that can block the activity of various proteases. As ASB-1 is involved in protein degradation, inhibiting protease activity can disrupt the process and potentially affect ASB-1's function. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is another proteasome inhibitor. By inhibiting the proteasome, it can disrupt ASB-1's function in protein degradation and turnover. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a specific proteasome inhibitor that can disrupt protein degradation. Like other proteasome inhibitors, it can potentially disrupt the function of ASB-1. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619 is a broad-spectrum deubiquitinase inhibitor. By inhibiting deubiquitinases, it can disrupt the balance of ubiquitination and deubiquitination processes, which are crucial for the function of E3 ubiquitin ligases like ASB-1. | ||||||
Chloroquine Sulphate | 132-73-0 | sc-337629 | 25 mg | $224.00 | 2 | |
Chloroquine can affect the pH of intracellular compartments like lysosomes. By disrupting lysosomal function, it can affect the degradation of proteins marked for destruction by E3 ubiquitin ligases like ASB-1. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 is a NEDD8-activating enzyme inhibitor. NEDD8 is a ubiquitin-like protein that modifies cullin proteins. As cullin proteins are part of the Cullin-RING E3 ubiquitin ligases, which ASB-1 is a member of, inhibiting NEDD8 can affect ASB-1 function. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin is a Thioredoxin reductase inhibitor. This enzyme is necessary for maintaining the reduced state of many proteins. Its inhibition can lead to oxidative stress and thereby affect the function of many proteins, including ASB-1. | ||||||