ART4 Inhibitors
ART4 inhibitors are a class of chemical compounds that target and inhibit the activity of ADP-ribosyltransferase 4 (ART4), an enzyme responsible for catalyzing the transfer of ADP-ribose from NAD⁺ to specific protein substrates. ART4 plays a role in the post-translational modification process known as ADP-ribosylation, which can affect the activity, stability, and interactions of proteins within cells. By inhibiting ART4, these compounds interfere with the enzyme's ability to modify its protein targets, thereby blocking ADP-ribosylation. This can lead to changes in the protein's function or interaction networks, making ART4 inhibitors useful for understanding how ADP-ribosylation contributes to cellular processes such as signal transduction and protein regulation.
The inhibition of ART4 can disrupt various cellular mechanisms, as ADP-ribosylation is integral to modulating protein functions, including protein-protein interactions and cellular communication pathways. ART4 inhibitors block the enzyme's activity by either binding to its active site or interfering with its regulatory domains, preventing the transfer of ADP-ribose to target proteins. The inhibition of ART4 is particularly useful in research aimed at unraveling the specific roles of this enzyme in complex biological pathways. By preventing ADP-ribosylation, ART4 inhibitors enable scientists to study the downstream effects on protein activity, conformational changes, and intracellular signaling. These inhibitors serve as critical tools for exploring how ADP-ribosylation orchestrates diverse cellular functions and protein dynamics, providing valuable insights into the molecular mechanisms that underlie cellular regulation and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide might competitively inhibit the activity of ART4 by providing an alternative substrate for NAD+, potentially decreasing ART4 function. | ||||||
3-Aminobenzamide | 3544-24-9 | sc-3501 sc-3501B sc-3501A | 100 mg 1 g 5 g | $15.00 $37.00 $52.00 | 18 | |
This compound could hinder PARP enzymes, which share mechanistic similarities with ART4, possibly leading to a decrease in ART4-mediated ADP-ribosylation. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate may disrupt nucleotide biosynthesis by inhibiting dihydrofolate reductase, which could result in reduced expression of ART4 due to lower availability of nucleotides for mRNA synthesis. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $153.00 $464.00 | 20 | |
As a kinase inhibitor, 5-Iodotubercidin may interfere with signaling pathways that promote ART4 transcription, thereby potentially decreasing its expression. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
Ribavirin may deplete cellular NAD+ pools by inhibiting inosine monophosphate dehydrogenase, which could lead to reduced enzymatic activity of ART4 due to lack of essential cofactor. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A could bind to DNA in the promoter region of ART4, obstructing the binding of transcription factors necessary for ART4 gene transcription, thus reducing its expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
By inhibiting histone deacetylases, Trichostatin A may lead to a more condensed chromatin structure around the ART4 gene, hindering its transcription and consequently decreasing expression levels. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D may intercalate into DNA strands, particularly at GC-rich regions, which could inhibit the transcription elongation process of the ART4 gene, leading to downregulation of ART4 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2′-Deoxycytidine could induce hypomethylation of the ART4 gene promoter, potentially disrupting the binding of methylation-sensitive repressors, thereby downregulating ART4 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid may cause the accumulation of acetylated histones in the chromatin of the ART4 gene, resulting in reduced transcriptional activity and lower ART4 protein levels. | ||||||