Arp3C Activators encompass a range of compounds that indirectly influence the functional activity of Arp3C, primarily through their effects on the actin cytoskeleton and associated cellular processes. Compounds that affect actin dynamics, such as Jasplakinolide, Cytochalasin D, Latrunculin A, Swinholide A, and Phalloidin, are significant in this context. Jasplakinolide, as an F-actin stabilizer, and Phalloidin can influence Arp3C by stabilizing actin filaments, impacting cellular motility and structure. Conversely, Cytochalasin D and Latrunculin A, which disrupt actin polymerization, and Swinholide A, which severs actin filaments, might modulate Arp3C's role in cell morphology and movement. Inhibitors of the Arp2/3 complex, such as CK-666 and CK-869, are particularly important as they directly target the system in which Arp3C is involved. By inhibiting actin branching and network formation, these compounds could significantly impact Arp3C's activity in cellular processes like motility and structural organization.
Other compounds influencing cytoskeletal dynamics, such as Y-27632, a ROCK inhibitor, Blebbistatin, an inhibitor of myosin II, and ML-7, targeting myosin light chain kinase, can indirectly affect Arp3C's function. These inhibitors modulate cellular contractility and actin-myosin interactions, thereby influencing Arp3C's role in the actin network formation. Additionally, agents affecting microtubule dynamics, such as Nocodazole and Paclitaxel, can also indirectly influence Arp3C. Nocodazole, by destabilizing microtubules, and Paclitaxel, by stabilizing them, might affect the crosstalk between microtubules and the actin cytoskeleton, thereby influencing Arp3C's function in cellular structure and dynamics.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide, a stabilizer of F-actin, can indirectly influence Arp3C's function in actin polymerization and cytoskeletal rearrangements, impacting cellular motility and structure. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D, an inhibitor of actin polymerization, might affect Arp3C by disrupting actin dynamics, impacting its role in cell morphology and movement. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A, an actin monomer-binding compound, can indirectly modulate Arp3C activity by affecting actin filament formation and stability. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A, an actin filament-severing compound, might influence Arp3C indirectly by altering actin cytoskeleton dynamics, impacting cellular processes. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $229.00 | 33 | |
Phalloidin, a toxin that stabilizes actin filaments, could indirectly affect Arp3C's function in actin polymerization and cellular structure regulation. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
CK-666, an Arp2/3 complex inhibitor, could impact Arp3C by inhibiting actin branching and network formation, affecting cell motility and structure. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $160.00 | ||
CK-869, another Arp2/3 complex inhibitor, might modulate Arp3C's activity in actin filament branching and organization. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632, a ROCK inhibitor, could indirectly influence Arp3C activity by modulating cytoskeletal dynamics and cell contractility, impacting actin network formation. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Blebbistatin, an inhibitor of myosin II, might affect Arp3C indirectly by altering cellular contractility and actin-myosin interactions. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7, an inhibitor of myosin light chain kinase, could influence Arp3C's function in actin cytoskeleton regulation and cell motility. |