ARMCX3 Inhibitors
ARMCX3 Inhibitors are a class of compounds that can directly or indirectly decrease the functional activity of ARMCX3. ARMCX3 is involved in various biological processes and is influenced by several signaling pathways. One such pathway is modulated by protein kinase C (PKC), an enzyme inhibited by Staurosporine. PKC regulates various cellular functions, and its inhibition disrupts these processes, leading to decreased ARMCX3 activity. Genistein, a tyrosine kinase inhibitor, can inhibit ARMCX3 if its activity is mediated by tyrosine phosphorylation. Genistein prevents this phosphorylation, disrupting the associated signaling pathways and decreasing ARMCX3 activity.
The inhibitors LY294002 and Wortmannin target the phosphatidylinositol 3-kinase (PI3K) pathway, which has been shown to regulate numerous cellular processes. Their action can lead to decreased ARMCX3 activity by blocking PI3K, disrupting the downstream signaling pathways that are critical for ARMCX3 activity. Similarly, rapamycin, an mTOR inhibitor, can also disrupt ARMCX3 activity, as mTOR is a master regulator of cellular growth and metabolism. MEK inhibitors such as U0126, PD98059, Trametinib, and Selumetinib can lead to decreased ARMCX3 activity by inhibiting the ERK1/2 signaling pathway, which has involvement in the regulation of ARMCX3. Additionally, the p38 MAPK inhibitor, SB203580, and the JNK inhibitor, SP600125, can disrupt the associated signaling pathways that contribute to ARMCX3 activity, leading to decreased functional activity of ARMCX3. Lastly, BAY 11-7082, which inhibits NF-κB activation, disrupts the associated signaling pathways contributing to ARMCX3 activity, leading to decreased ARMCX3 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits protein kinase C (PKC). PKC regulates various cellular functions, including ARMCX3. Inhibiting PKC disrupts these processes, potentially leading to decreased ARMCX3 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can inhibit ARMCX3 if its activity is mediated by tyrosine phosphorylation. Genistein prevents this phosphorylation, disrupting the associated signaling pathways and potentially decreasing ARMCX3 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. It can decrease ARMCX3 activity by blocking PI3K, disrupting the downstream signaling pathways that are critical for ARMCX3 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a regulator of cellular growth and metabolism. By blocking mTOR, the signaling pathways that contribute to ARMCX3 activity are disrupted, potentially leading to decreased ARMCX3 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, the associated signaling pathways that contribute to ARMCX3 activity are disrupted, potentially leading to decreased functional activity of ARMCX3. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. By blocking JNK, it disrupts the JNK pathway, potentially decreasing the functional activity of ARMCX3. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor. It blocks the MAPK signaling pathway, which could be involved in the regulation of ARMCX3, potentially leading to decreased functional activity of ARMCX3. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor. By blocking PI3K, it disrupts downstream signaling pathways that may be critical for ARMCX3 activity, potentially leading to decreased functional activity of ARMCX3. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation. By inhibiting this pathway, it disrupts the associated signaling pathways contributing to ARMCX3 activity, potentially leading to decreased ARMCX3 activity. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $112.00 $163.00 $928.00 | 19 | |
Trametinib is a MEK inhibitor. By inhibiting MEK, it disrupts the MAPK/ERK pathway which could be involved in the regulation of ARMCX3, potentially leading to decreased functional activity of ARMCX3. | ||||||