ARL4 Activators
ARL4 activators are a group of chemicals that can directly or indirectly enhance the functional activity of ARL4. They influence a variety of signaling pathways and biological processes, significantly impacting the function of ARL4. Phorbol 12-myristate 13-acetate (PMA), for example, is a potent activator of protein kinase C (PKC), which can phosphorylate ARL4, thereby enhancing its GTP binding and function.
Moreover, LY294002 reduces PIP3 levels, enhancing ARL4 function due to reduced PIP3-mediated suppression. Forskolin, an activator of adenylyl cyclase, can increase cAMP levels, which in turn activate PKA that can phosphorylate ARL4, enhancing its function. Calyculin A and Okadaic acid, can enhance ARL4 function by increasing phosphorylation levels. Rapamycin, Metformin, and AICAR, all of which inhibit mTOR, can lead toreduced phosphorylation of 4E-BP1, which can enhance the translation of ARL4 mRNA. Lastly, U0126 and PD98059 can enhance ARL4 function by reducing ERK-mediated inhibitory phosphorylation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent PKC activator. PKC can phosphorylate ARL4, enhancing its GTP binding and function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, which can increase cAMP levels. Increased cAMP can activate PKA, which can phosphorylate ARL4, enhancing its function. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent protein phosphatase inhibitor. By inhibiting protein phosphatases, it can enhance the phosphorylation and activation of ARL4. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent protein phosphatase inhibitor. It can enhance ARL4 function by increasing phosphorylation levels. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin activates AMPK, which can inhibit mTORC1. This can lead to reduced phosphorylation of 4E-BP1, which can enhance the translation of ARL4 mRNA. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMPK activator. Activation of AMPK can inhibit mTORC1, leading to enhanced translation of ARL4 mRNA due to reduced phosphorylation of 4E-BP1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor. It can enhance ARL4 function by reducing ERK-mediated inhibitory phosphorylation. | ||||||