ARL4 Inhibitors
ARL4 Inhibitors are a group of chemical compounds that primarily work through the modulation of intracellular trafficking processes and the PI3K/Akt signaling pathway. Chemicals that disrupt the structure and function of the Golgi apparatus, such as Brefeldin A, or inhibit the transport of vesicles to the plasma membrane, such as Exo2, can inhibit the functional activity of ARL4, as it relies on these processes for its transportation to the plasma membrane. Additionally, inhibitors of dynamin, such as Dyngo 4a and Dynasore, can disrupt the endocytic pathway that ARL4 is involved in, leading to decreased functional activity of ARL4.
On the other hand, inhibitors of cytohesin and GBF1, such as SecinH3 and Golgicide A, respectively, can disrupt the ARF-dependent endocytic pathway whereARL4 functions, leading to decreased functional activity of ARL4. There are also several compounds, including Wortmannin, LY294002, and Rapamycin, that act as inhibitors of the PI3K/Akt signaling pathway. This pathway is crucial for the membrane localization and functional activity of ARL4. Thus, by inhibiting the PI3K/Akt pathway, these compounds can indirectly inhibit ARL4's function. Similarly, U73122, an inhibitor of phospholipase C (PLC), can affect the functional activity of ARL4, as PLC plays a role in the regulation of ARF GTPases such as ARL4.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is a fungal metabolite that disrupts the structure and function of the Golgi apparatus. By doing so, it can inhibit the transport of ARL4 to the plasma membrane, indirectly inhibiting the functional activity of ARL4. | ||||||
Exo2 | 304684-77-3 | sc-215011 sc-215011A | 5 mg 25 mg | $89.00 $288.00 | 1 | |
Exo2 is a small molecule inhibitor of the exocyst complex, which is involved in the transport of vesicles to the plasma membrane. It can reduce the function of this pathway, thus indirectly inhibiting the functional activity of ARL4 which is involved in intracellular trafficking. | ||||||
Hydroxy-Dynasore | 1256493-34-1 | sc-364678 | 10 mg | $255.00 | ||
Dyngo 4a is a potent inhibitor of dynamin, a large GTPase that is essential for clathrin-mediated endocytosis. By inhibiting dynamin, Dyngo 4a can disrupt the endocytic pathway that ARL4 is involved in, thus indirectly inhibiting the functional activity of ARL4. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a non-competitive inhibitor of the GTPase activity of dynamin. By inhibiting dynamin, dynasore can disrupt the endocytic pathway that ARL4 is involved in, thus indirectly inhibiting the functional activity of ARL4. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
SecinH3 is an inhibitor of cytohesin, a family of guanine nucleotide exchange factors (GEFs) for ARF GTPases. By inhibiting cytohesin, it can disrupt the ARF-dependent endocytic pathway where ARL4 functions, leading to decreased functional activity of ARL4. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $191.00 $683.00 | 11 | |
Golgicide A is a specific inhibitor of the ARF1-GEF GBF1, which can disrupt ARF-dependent endocytic pathway where ARL4 functions, leading to decreased functional activity of ARL4. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent, irreversible inhibitor of PI3K, a key enzyme in the PI3K/Akt pathway. Through this, it can indirectly inhibit ARL4, which is dependent on PI3K/Akt signaling for its membrane localization and function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of PI3K, a key enzyme in the PI3K/Akt pathway. By inhibiting PI3K, it can indirectly affect ARL4’s membrane localization and function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an inhibitor of mTOR, a key protein in the PI3K/Akt pathway. By inhibiting mTOR, it can indirectly affect ARL4’s membrane localization and function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a potent inhibitor of protein tyrosine kinases, which are involved in the regulation of GTPases such as ARL4. By inhibiting these kinases, it can indirectly affect the functional activity of ARL4. | ||||||