ARID1B Inhibitors
ARID1B Inhibitors include a range of compounds that can suppress or modulate the expression and activity of ARID1B. This class encompasses mTOR inhibitors like Sirolimus (Rapamycin), DNA-binding agents such as Mithramycin A, and agents like 5-Fluorouracil and Doxorubicin, which inhibit DNA synthesis and disrupt transcription, affecting ARID1B expression.
HDAC inhibitors like Vorinostat and Romidepsin, known to impact chromatin structure and gene expression, could reduce ARID1B in certain contexts. Natural compounds such as Curcumin, with its broad spectrum of biological activities, and drugs like Chloroquine, with effects on DNA replication, are considered for their impact on ARID1B. Bortezomib, a proteasome inhibitor, Bevacizumab, an angiogenesis inhibitor, and Paclitaxel, a microtubule inhibitor, are included for their roles in modulating various cellular processes that could impact ARID1B expression and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Known to bind DNA and inhibit transcription, potentially reducing ARID1B expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
A chemotherapeutic agent that inhibits DNA synthesis, potentially downregulating ARID1B expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
An HDAC inhibitor that changes chromatin structure and gene expression patterns, potentially leading to the downregulation of ARID1B. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Known for its anti-inflammatory and antioxidant effects, curcumin can modulate various signaling pathways, potentially leading to the inhibition of ARID1B. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Another HDAC inhibitor that can alter gene expression, potentially affecting ARID1B. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
An anthracycline chemotherapeutic, known to intercalate into DNA and disrupt transcription, potentially affecting ARID1B expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can affect various cellular processes, potentially downregulating ARID1B. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
A chemotherapeutic agent that disrupts microtubule function, potentially influencing ARID1B activity indirectly through cell cycle regulation. | ||||||