ARH2 Activators
ARH2 activators encompass a diverse group of chemical compounds that indirectly facilitate the enhancement of ARH2's functional activity through various signaling pathways. Forskolin, for instance, elevates intracellular cAMP levels, which in turn activate protein kinase A (PKA). PKA phosphorylates downstream proteins that interact with ARH2, enhancing ARH2's role in cellular signaling. Epigallocatechin gallate, a kinase inhibitor, reduces competitive inhibitory signaling, thereby allowing ARH2 pathways to become more dominant in cell signaling. Similarly, the PI3K inhibitor LY294002 redirects intracellular signaling towards ARH2-involved pathways, thereby augmenting its role in cell growth and survival. Ionomycin and Thapsigargin, by increasing intracellular calcium levels, activate calcium-dependent pathways that intersect with those involving ARH2, thus enhancing its activity in cell stress responses and other processes.
The functional activity of ARH2 is further influenced by compounds that modulate specific signaling kinases and phosphatases. PMA, a PKC activator, and U0126, a MEK inhibitor, both alter the signaling equilibrium in the cell, promoting pathways where ARH2 plays a crucial role. SB203580, through its inhibitory action on p38 MAPK, reduces competition from p38 MAPK-dependent pathways, indirectly enhancing ARH2's function. Genistein and Staurosporine, by inhibiting tyrosine kinases and a spectrum of other kinases respectively, lift the inhibition on ARH2-related processes, leading to an increase in ARH2's signaling activity. Sphingosine-1-phosphate, through its effect on lipid signaling, and A23187, a calcium ionophore, further enhance ARH2 activity by influencing pathways that intersect with ARH2's role in cellular signaling, highlighting the complex yet coordinated regulation of ARH2 through these diverse chemical activators.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, through the elevation of cAMP levels, indirectly enhances ARH2 activity by stimulating cAMP-dependent protein kinase A (PKA). PKA then phosphorylates and activates downstream proteins that interact with ARH2, leading to the enhancement of ARH2's function in cellular signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This polyphenol inhibits certain types of kinases, thus reducing competitive inhibitory signaling. This inhibition allows ARH2 pathways to become more prominent in cellular processes like signal transduction, thereby enhancing the functional activity of ARH2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
As a PI3K inhibitor, LY294002 shifts the balance of intracellular signaling towards pathways in which ARH2 is involved. This redirection of signaling enhances the role of ARH2 in processes like cell growth and survival. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which in turn activates calcium-dependent signaling pathways. These pathways can interact with and enhance the signaling cascades involving ARH2, thereby indirectly increasing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA, as an activator of protein kinase C (PKC), modulates signaling pathways where ARH2 is a key player. The activation of PKC leads to a cascade of events that enhance the functional role of ARH2 in cellular processes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
This MEK inhibitor shifts the signaling dynamics in the cell by downregulating the MAPK pathway. This modulation can indirectly enhance ARH2 activity by reducing competitive signaling pathways and highlighting ARH2's role in cellular communication. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, by inhibiting p38 MAPK, alters the intracellular signaling landscape. This alteration can enhance the functional role of ARH2 in the cell by reducing competition from p38 MAPK-dependent pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin increases intracellular calcium levels, indirectly influencing calcium-dependent pathways that interact with ARH2. This interaction enhances ARH2's role in signaling pathways related to cell stress responses. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, lessens the activity of competing signaling pathways. This reduction potentially elevates the role of ARH2 in cellular signaling, particularly in processes like cellular growth and response to environmental stimuli. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This compound modulates lipid signaling pathways, which intersect with pathways involving ARH2. Such modulation can lead to an enhancement of ARH2's functional activity in processes like cell migration and survival. | ||||||