AQP3 Inhibitors
AQP3 inhibitors are a diverse group of compounds that indirectly influence the functionality of AQP3, a key membrane transporter of water and glycerol. These inhibitors do not directly target AQP3 but rather impact its function through various biochemical and cellular mechanisms. Compounds such as Mercury(II) chloride, Phloretin, Copper sulfate, Silver nitrate, and Gold(III) chloride inhibit AQP3 by interacting with its channel structure, thereby affecting its permeability to water and glycerol. This interaction is crucial in modulating the primary function of AQP3 in osmoregulation and skin hydration.
Additionally, compounds like Tannic acid, Acetazolamide, and diuretics (e.g., Bumetanide, Furosemide, and Amiloride) exert their effects by altering the cellular environment in which AQP3 operates. For instance, Acetazolamide affects cellular pH and ion balance, which can influence AQP3 channel function, while diuretics modify osmotic gradients and ion homeostasis, impacting the role of AQP3 in water transport. Furthermore, compounds such as Forskolin and Tetraethylammonium chloride (TEA) modulate signaling pathways and membrane potentials, respectively, providing indirect avenues to influence AQP3 activity. These mechanisms collectively contribute to the regulation of AQP3's function in various tissues, underscoring the importance of these inhibitors in modulating water and glycerol transport essential for cellular homeostasis and function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $64.00 $255.00 | 13 | |
Phloretin, a dihydrochalcone found in apple tree leaves, inhibits various aquaporins. It can indirectly inhibit AQP3 by interfering with its channel permeability to water and glycerol. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper sulfate can inhibit aquaporin function. It may indirectly inhibit AQP3 by interacting with its channel structure and affecting its transport capabilities. | ||||||
Silver nitrate | 7761-88-8 | sc-203378 sc-203378A sc-203378B | 25 g 100 g 500 g | $114.00 $378.00 $1081.00 | 1 | |
Silver nitrate is known to inhibit aquaporins. It could indirectly inhibit AQP3 by binding to the channel and interfering with its water and glycerol transport function. | ||||||
Gold(III) chloride | 13453-07-1 | sc-250066 | 250 mg | $56.00 | ||
Gold(III) chloride can inhibit aquaporins by interacting with their channel structures. It could indirectly inhibit AQP3's water and glycerol transporting activity. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
Tannic acid, a polyphenol, has been shown to affect aquaporin function. It may indirectly inhibit AQP3 by altering the channel's structure or its interaction with the cellular membrane. | ||||||
Acetazolamide | 59-66-5 | sc-214461 sc-214461A sc-214461B sc-214461C sc-214461D sc-214461E sc-214461F | 10 g 25 g 100 g 250 g 500 g 1 kg 2 kg | $81.00 $177.00 $434.00 $541.00 $883.00 $1479.00 $2244.00 | 1 | |
Acetazolamide, a carbonic anhydrase inhibitor, can influence water transport. It could indirectly affect AQP3 by altering cellular pH and ion balance, which might affect AQP3 channel function. | ||||||
Tetraethylammonium chloride | 56-34-8 | sc-202834 | 25 g | $45.00 | 2 | |
TEA, a potassium channel blocker, can indirectly affect AQP3 by altering membrane potential and thus influencing the cellular environment in which AQP3 operates. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $109.00 $228.00 | 9 | |
Bumetanide, a loop diuretic, affects ion transport and could indirectly influence AQP3 by altering osmotic gradients and cellular ion homeostasis, potentially affecting AQP3 function. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $41.00 | ||
Furosemide, another loop diuretic, can indirectly affect AQP3 by altering the osmotic balance in cells, which might impact AQP3's role in osmoregulation. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Amiloride, a diuretic affecting sodium transport, could indirectly inhibit AQP3 by modifying the electrochemical gradients across cell membranes, potentially affecting AQP3-mediated water and glycerol transport. | ||||||