Date published: 2026-6-8

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APPL Antibodies

Santa Cruz Biotechnology features a diverse variety of APPL Antibodies for advanced research in cellular signaling and protein interactions. Monoclonal APPL Antibodies are compatible with multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). APPL proteins function in intracellular trafficking and signaling pathways, particularly in insulin signaling and glucose metabolism. Understanding APPL protein mechanisms has become essential for metabolic disorder research and therapeutic development. APPL proteins regulate cell survival pathways and influence various cellular responses to external stimuli. Research has shown APPL proteins participate in endosomal trafficking and membrane protein transport. Ongoing studies continue to reveal new roles for APPL proteins in cell signaling networks and disease progression. APPL monoclonal antibodies from Santa Cruz Biotechnology enable researchers worldwide to advance scientific understanding of cellular processes and potential therapeutic applications.

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APPL Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

APPL1 Antibody (A-1)

sc-271901mouse IgG1 κ614-709 (h)WB, IP, IF, ELISAm, r, h
7
(8)

APPL1 Antibody (H-3)

sc-271909mouse IgG3 κ614-709 (h)WB, IP, IF, ELISAm, r, h

new

(2)

APPL2 Antibody (F-2)

sc-398859mouse IgG2a κ31-54 (h)WB, IP, IF, ELISAm, r, h
1
(3)

APPL2 Antibody (B-12)

sc-398860mouse IgG2b κ31-54 (h)WB, IP, IF, ELISAm, r, h

new

(2)

APPL2 Antibody (E-1)

sc-271084mouse IgG1 κ605-664 (h)WB, IP, IF, IHC(P), ELISAm, r, h
1
(3)

APPL CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

APPL1 Double Nickase Plasmid (m)

sc-428481-NICmGene KnockoutPuromycin0
(0)

APPL1 Double Nickase Plasmid (m2)

sc-428481-NIC-2mGene KnockoutPuromycin0
(0)

APPL2 CRISPR/Cas9 KO Plasmid (h)

sc-402991hGene KnockoutGFP0
(0)

APPL2 HDR Plasmid (h)

sc-402991-HDRhHomology Directed RepairPuromycin0
(0)

APPL2 CRISPR/Cas9 KO Plasmid (m)

sc-432068mGene KnockoutGFP0
(0)

APPL2 HDR Plasmid (m)

sc-432068-HDRmHomology Directed RepairPuromycin0
(0)

APPL CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

APPL1 CRISPR Activation Plasmid (h)

sc-402243-ACThGene ActivationPuro, Blast, Hygro0
(0)

APPL1 CRISPR Activation Plasmid (m)

sc-428481-ACTmGene ActivationPuro, Blast, Hygro0
(0)

APPL1 Lentiviral Activation Particles (m)

sc-428481-LACmGene ActivationPuro, Blast, Hygro0
(0)

APPL2 CRISPR Activation Plasmid (m2)

sc-432068-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

APPL siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

APPL1 siRNA (h)

sc-61980hGene SilencingN/A
2
(0)

APPL1 shRNA Plasmid (h)

sc-61980-SHhGene SilencingPuromycin
2
(0)

APPL1 shRNA (h) Lentiviral Particles

sc-61980-VhGene SilencingPuromycin
2
(0)

APPL1 siRNA (m)

sc-61981mGene SilencingN/A
2
(0)

APPL1 shRNA Plasmid (m)

sc-61981-SHmGene SilencingPuromycin
2
(0)

APPL1 shRNA (m) Lentiviral Particles

sc-61981-VmGene SilencingPuromycin
2
(0)

APPL2 siRNA (h)

sc-61982hGene SilencingN/A0
(0)

APPL2 shRNA Plasmid (h)

sc-61982-SHhGene SilencingPuromycin0
(0)

APPL2 shRNA (h) Lentiviral Particles

sc-61982-VhGene SilencingPuromycin0
(0)

APPL2 siRNA (m)

sc-61983mGene SilencingN/A0
(0)

APPL2 shRNA Plasmid (m)

sc-61983-SHmGene SilencingPuromycin0
(0)

APPL2 shRNA (m) Lentiviral Particles

sc-61983-VmGene SilencingPuromycin0
(0)