Date published: 2026-7-24

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APPL Antibodies

Santa Cruz Biotechnology features a diverse variety of APPL Antibodies for advanced research in cellular signaling and protein interactions. Monoclonal APPL Antibodies are compatible with multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). APPL proteins function in intracellular trafficking and signaling pathways, particularly in insulin signaling and glucose metabolism. Understanding APPL protein mechanisms has become essential for metabolic disorder research and therapeutic development. APPL proteins regulate cell survival pathways and influence various cellular responses to external stimuli. Research has shown APPL proteins participate in endosomal trafficking and membrane protein transport. Ongoing studies continue to reveal new roles for APPL proteins in cell signaling networks and disease progression. APPL monoclonal antibodies from Santa Cruz Biotechnology enable researchers worldwide to advance scientific understanding of cellular processes and potential therapeutic applications.

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APPL Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

APPL1 Antibody (A-1)

sc-271901mouse IgG1 κ614-709 (h)WB, IP, IF, ELISAm, r, h
7
(8)

APPL1 Antibody (H-3)

sc-271909mouse IgG3 κ614-709 (h)WB, IP, IF, ELISAm, r, h

new

(2)

APPL2 Antibody (F-2)

sc-398859mouse IgG2a κ31-54 (h)WB, IP, IF, ELISAm, r, h
1
(3)

APPL2 Antibody (B-12)

sc-398860mouse IgG2b κ31-54 (h)WB, IP, IF, ELISAm, r, h

new

(2)

APPL2 Antibody (E-1)

sc-271084mouse IgG1 κ605-664 (h)WB, IP, IF, IHC(P), ELISAm, r, h
1
(3)

APPL siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

APPL1 siRNA (h)

sc-61980hGene SilencingN/A
2
(0)

APPL1 shRNA Plasmid (h)

sc-61980-SHhGene SilencingPuromycin
2
(0)

APPL1 shRNA (h) Lentiviral Particles

sc-61980-VhGene SilencingPuromycin
2
(0)

APPL1 siRNA (m)

sc-61981mGene SilencingN/A
2
(0)

APPL1 shRNA Plasmid (m)

sc-61981-SHmGene SilencingPuromycin
2
(0)

APPL1 shRNA (m) Lentiviral Particles

sc-61981-VmGene SilencingPuromycin
2
(0)

APPL2 siRNA (h)

sc-61982hGene SilencingN/A0
(0)

APPL2 shRNA Plasmid (h)

sc-61982-SHhGene SilencingPuromycin0
(0)

APPL2 shRNA (h) Lentiviral Particles

sc-61982-VhGene SilencingPuromycin0
(0)

APPL2 siRNA (m)

sc-61983mGene SilencingN/A0
(0)

APPL2 shRNA Plasmid (m)

sc-61983-SHmGene SilencingPuromycin0
(0)

APPL2 shRNA (m) Lentiviral Particles

sc-61983-VmGene SilencingPuromycin0
(0)

APPL CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

APPL2 CRISPR/Cas9 KO Plasmid (h)

sc-402991Gene Knockouth0
(0)

APPL2 HDR Plasmid (h)

sc-402991-HDRHomology Directed Repairh0
(0)

APPL2 CRISPR/Cas9 KO Plasmid (m)

sc-432068Gene Knockoutm0
(0)

APPL2 HDR Plasmid (m)

sc-432068-HDRHomology Directed Repairm0
(0)

APPL CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

APPL1 Double Nickase Plasmid (m)

sc-428481-NICGene Knockoutm0
(0)

APPL1 Double Nickase Plasmid (m2)

sc-428481-NIC-2Gene Knockoutm0
(0)

APPL CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

APPL1 CRISPR Activation Plasmid (h)

sc-402243-ACTGene Activationh0
(0)

APPL1 CRISPR Activation Plasmid (m)

sc-428481-ACTGene Activationm0
(0)

APPL1 Lentiviral Activation Particles (m)

sc-428481-LACGene Activationm0
(0)

APPL2 CRISPR Activation Plasmid (m2)

sc-432068-ACT-2Gene Activationm0
(0)