APPL1 Antibody (H-3): sc-271909

APPL1 Antibody (H-3) is a mouse monoclonal IgG3 antibody that detects APPL1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). APPL1, also known as adaptor protein containing pH domain, PTB domain, and leucine zipper motif 1, plays a crucial role in cellular signaling and trafficking, particularly in epidermal growth factor (EGF) signaling and chromatin remodeling within the nucleus. APPL1 enables coupling of EGF signaling pathways to downstream effects, which are vital for cell growth and proliferation. APPL1 primarily resides in the cytoplasm but translocates to the nucleus upon activation, where APPL1 interacts with the NuRD/MeCP1 complex, further influencing gene expression and cellular responses. Additionally, APPL1 regulates the Akt signaling pathway by binding to kinase domains of Akt1 and Akt2, and interacts with neurotrophin receptors and follicle-stimulating hormone receptors, highlighting a multifaceted role in various signaling networks. With high expression levels in tissues such as heart, ovary, skeletal muscle, and pancreas, APPL1 maintains cellular functions and responds to external signals. Anti-APPL1 antibody (H-3) serves as an invaluable tool for researchers exploring APPL1′s intricate roles in cellular processes and implications in health and disease.

The preferred APPL1 antibody is APPL1 Antibody (A-1): sc-271901.