APC11 Activators
The term APC11 Activators refers to chemical compounds that could modulate the activity or expression of APC11, a component of the Anaphase-Promoting Complex/Cyclosome (APC/C). APC11 has a critical role within this complex, affecting various cellular processes related to ubiquitination and deubiquitination. These substances might interact with APC11 directly or potentially influence it by modulating related biological pathways and processes. For example, Bortezomib, known as a proteasome inhibitor, could influence APC11 activity by leading to the accumulation of ubiquitinated proteins, thus impacting the substrate availability for the APC/C complex. Another agent, PYR-41, an inhibitor of ubiquitin-activating enzyme E1, might alter ubiquitin dynamics and, thereby, potentially influence the functionality of APC11 within the APC/C complex.
Substances like Rapamycin and Metformin may exert influence by modifying cellular signaling and energy status, respectively, potentially affecting the environment and conditions in which APC11 operates. Rapamycin, an mTOR inhibitor, and Metformin, an AMPK activator, might respectively alter cellular growth pathways and energy dynamics, providing potential modulation points for APC11's functionality and expression. Additionally, substances like Vorinostat and Wortmannin may potentially modulate APC11 activity through alterations in acetylation states and cellular survival pathways, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
PYR-41 inhibits ubiquitin-activating enzyme E1, potentially altering ubiquitin dynamics, which may influence the functionality of the APC/C complex and, therefore, indirectly impact APC11. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a CDK4/6 inhibitor, impacting cell cycle regulation, potentially affecting the activation times and substrates for APC/C and hence APC11 indirectly. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, potentially affecting cellular growth and survival pathways, altering the cellular environment in which APC/C and APC11 operate. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV-939 is a Wnt pathway inhibitor, potentially impacting cellular differentiation and development processes that may have a knock-on effect on the activity of APC11 within the APC/C complex. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin induces DNA damage and activates repair mechanisms, potentially affecting cell cycle progression and indirectly the activity of APC11 within the APC/C complex. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is an HDAC inhibitor, potentially altering gene expression and protein interactions, which could influence the APC/C complex and hence APC11 indirectly. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin is an HSP90 inhibitor, potentially affecting protein folding and stability, which might indirectly impact the functionality of APC11 within the APC/C complex. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor, potentially affecting cell survival and growth signaling pathways, altering the environment in which APC11 operates within the APC/C complex. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin is an AMPK activator, potentially altering cellular energy status and signaling, impacting ubiquitination/deubiquitination dynamics and possibly influencing APC11 indirectly. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082 inhibits the NF-κB pathway, potentially affecting inflammation and stress response pathways, which could have downstream effects on APC11. | ||||||