AP2 Activators
AP2 Activators are a class of chemicals that enhance the functional activity of AP2, a transcription factor, through diverse mechanisms, primarily by modulating intracellular signaling. The activators can function via direct or indirect effects on AP2. For instance, certain activators like Forskolin and IBMX increase intracellular cAMP levels, which can in turn enhance the transcriptional activity of AP2. In contrast, Okadaic Acid and Calyculin A enhance AP2's DNA binding ability by inhibiting protein phosphatases and increasing the phosphorylation status of proteins.
Other activators like Genistein and Sodium Orthovanadate enhance AP2 by preventing its dephosphorylation or enhancing its phosphorylation, respectively. Furthermore, EGF activates the EGFR/ERK pathway leading to the phosphorylation and activation of AP2. Certain activators influence calcium signaling, a crucial cellular process. A23187, Thapsigargin, and Nifedipine function by modulating intracellular calcium concentrations which in turn can activate AP2. Lastly, Staurosporine and PMA affect AP2 activity by influencing various signaling pathways that impact AP2's phosphorylation and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a potent activator of adenylate cyclase, which increases intracellular cAMP levels. The upsurge in cAMP can activate AP2 by influencing transcriptional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, leading to increased levels of cAMP and cGMP in cells. The rise in cAMP concentration can enhance AP2 function by modulating transcriptional activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, which can lead to phosphorylation of AP2, enhancing its DNA binding ability. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatase 1 and 2A, leading to increased phosphorylation status of proteins, including AP2, thus enhancing its DNA binding activity. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate is a potent inhibitor of protein tyrosine phosphatases, leading to enhanced tyrosine phosphorylation of proteins, including AP2, thus increasing its activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can prevent dephosphorylation of AP2, thereby enhancing its DNA binding ability. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, which can lead to the activation of calcium-dependent signal pathways involving AP2. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor, causing an increase in cytosolic calcium concentration which can activate calcium-dependent signal pathways involving AP2. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is an L-type calcium channel blocker that can indirectly enhance the activity of AP2 by modulating intracellular calcium signaling. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent protein kinase inhibitor that can enhance AP2 activity by affecting multiple signaling pathways impacting AP2 phosphorylation and function. | ||||||