AP1S2_Ap1s2 Activators
AP1S2 Activators consists of a diverse set of compounds that influence the functional activity of AP1S2 via unique and specific signaling pathways. Many of these compounds exert their influence by inhibiting the activity of proteins that act upstream of AP1S2 in various cellular signaling pathways, thereby indirectly enhancing the activity of AP1S2. For instance, PD 98059, a selective inhibitor of MEK, and U0126, a selective inhibitor of both MEK1 and MEK2, enhance the activity of AP1S2 by inhibiting proteins upstream of AP1S2 in the MAPK/ERK pathway.
Other compounds in this class act on different pathways. For example, LY294002 and Wortmannin are potent inhibitors of PI3K, and they enhance AP1S2 activity through the PI3K/AKT pathway. Similarly, Y-27632, a selective inhibitor of ROCK, enhances AP1S2 activity through the Rho signaling pathway, while NSC 23766 enhances AP1S2 activity by inhibiting Rac1 in the Rac1 signaling pathway. In essence, the compounds in the AP1S2 Activators class have a broad range of targets and mechanisms of action, but they all share the common theme ofApologies for the confusion earlier.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is a selective inhibitor of MEK, which is upstream of ERK in the MAPK pathway. By inhibiting MEK, this compound indirectly enhances the activity of AP1S2, which is known to be downstream in this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 inhibits p38 MAPK, a protein upstream of AP1S2 in the MAPK signaling pathway. Inhibition of p38 MAPK can enhance the activity of AP1S2. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a potent, selective and reversible inhibitor of JNK. By inhibiting JNK, this compound can indirectly enhance the activity of AP1S2, which is downstream of JNK in the MAPK pathway. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK, a protein involved in the Rho signaling pathway, where AP1S2 is also involved. By inhibiting ROCK, Y-27632 can enhance the activity of AP1S2. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go6983 is a broad spectrum Protein Kinase C (PKC) inhibitor that can enhance AP1S2 activity as AP1S2 is a downstream effector in the PKC pathway. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is a potent inhibitor of CaMKII, a protein that acts upstream of AP1S2 in the CaMKII signaling pathway. By inhibiting CaMKII, it can enhance the activity of AP1S2. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a Src family kinase inhibitor that can enhance AP1S2 activity as AP1S2 is a downstream effector in the Src signaling pathway. | ||||||