AP-4β Activators
AP-4β Activators encompass a variety of chemical agents that indirectly influence the activity of AP-4β by modifying cellular signaling pathways and trafficking dynamics. These agents are not directly interacting with AP-4β but are known to alter cellular environments or signaling cascades that are conducive to modulating the function of AP-4β as part of the AP-4 adaptor protein complex.
Compounds such as Forskolin and PMA exert their effects by stimulating signaling pathways that lead to the phosphorylation of proteins involved in vesicular trafficking, thereby creating a milieu that can affect the function and recruitment of AP-4β. AICAR, by activating AMPK, changes the energy status of the cell, which is known to have wide-reaching effects on vesicular transport processes, including those that could involve AP-4β. Similarly, agents that alter intracellular calcium levels, such as Ionomycin, may indirectly influence the activity of AP-4β by affecting calcium-dependent trafficking processes. Brefeldin A and Monensin disrupt organelle structure and function, thereby potentially modifying the role of AP-4β in membrane traffic. Other compounds like Retinoic acid, NAD+, Lithium chloride, and MG132 affect gene expression, cellular metabolism, and protein turnover, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Adenylate cyclase activator, raising cAMP levels, which can lead to PKA activation and subsequent phosphorylation of proteins involved in vesicular trafficking, potentially affecting AP-4β activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PKC activator that can modulate membrane trafficking and indirectly influence AP-4β by altering the membrane dynamics it interacts with. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AMPK activator which can affect cellular energy status and potentially enhance the recruitment of AP-4β to sites of vesicular budding. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Calcium ionophore that raises intracellular Ca2+ levels, affecting various calcium-dependent processes including membrane trafficking which could impact AP-4β function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Modulator of gene expression that could indirectly enhance the production of proteins that associate with AP-4β, influencing its function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts the Golgi apparatus, which can enhance retrograde trafficking and potentially impact AP-4β function as the cell responds to Golgi stress. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Ionophore that alters intracellular ion gradients and affects trafficking routes within the cell, which may influence AP-4β function. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
As a cofactor in redox reactions, elevated levels of NAD+ can affect overall cellular metabolism, which can influence membrane trafficking and AP-4β function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Glycogen synthase kinase-3 (GSK-3) inhibitor, which may affect vesicular trafficking pathways and potentially modulate AP-4β activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that can lead to accumulation of proteins within the cell, affecting cellular trafficking pathways and potentially influencing AP-4β activity. | ||||||