ANKRD18A inhibitors represent a specialized class of chemical compounds designed to modulate the activity of the ANKRD18A protein, which is involved in various cellular processes. This protein, characterized by the presence of ankyrin repeat domains, plays a crucial role in protein-protein interactions and the regulation of cellular signaling pathways. ANKRD18A inhibitors typically feature a diverse range of chemical structures, often comprising heterocyclic rings, aromatic systems, and specific functional groups that enhance binding affinity and selectivity for the target protein. The design of these inhibitors focuses on optimizing their interaction with the ANKRD18A protein, often employing techniques such as molecular docking and structure-activity relationship studies to identify optimal chemical scaffolds.
The approaches to creating ANKRD18A inhibitors often involve advanced chemistry methods, including multi-step synthesis and combinatorial chemistry. These inhibitors may exhibit varying degrees of potency and specificity, which are essential for understanding the biological roles of ANKRD18A in cellular contexts. Furthermore, the study of these compounds contributes to the broader understanding of cellular mechanisms by providing tools to dissect the functions of ANKRD18A. Research into this chemical class also involves examining the physicochemical properties of the compounds, such as solubility, stability, and permeability, to ensure their suitability for experimental applications. As a result, ANKRD18A inhibitors serve as valuable resources for researchers investigating the fundamental biology of the ANKRD18A protein and its involvement in various cellular processes.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This antibiotic binds to DNA and inhibits RNA polymerase, potentially decreasing ANKRD18A mRNA synthesis. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
This compound inhibits protein synthesis by blocking translocation during translation, potentially reducing ANKRD18A protein levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
As an mTOR inhibitor, rapamycin downregulates protein synthesis pathways, which could affect ANKRD18A expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This cytidine analog affects DNA methylation, which could lead to altered expression of genes including ANKRD18A. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylases, it affects chromatin structure and gene expression, potentially impacting ANKRD18A levels. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
This toxin inhibits RNA polymerase II, potentially reducing transcription of the ANKRD18A gene. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
It inhibits inosine monophosphate dehydrogenase, affecting nucleotide synthesis and potentially reducing RNA synthesis, including that of ANKRD18A. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
This antibiotic inhibits peptide bond formation on ribosomes, which would decrease overall protein synthesis including ANKRD18A. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
It inhibits DNA topoisomerase I, which is necessary for DNA replication and transcription, potentially affecting ANKRD18A expression. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
This compound selectively inhibits RNA polymerase II, which could lead to decreased transcription of the ANKRD18A gene. |