AMPKβ2 Activators
AMPKβ2 Activators represent a class of chemicals that indirectly influence the activity of the AMPKβ2 subunit, a component of the AMP-activated protein kinase complex. This group encompasses a diverse range of compounds, each engaging with cellular mechanisms to modulate the activity of AMPK, and consequently, the AMPKβ2 subunit. Metformin, a biguanide, is known for its role in enhancing cellular glucose uptake and improving insulin sensitivity, processes that are closely associated with AMPK activation. Similarly, AICAR, or Acadesine, functions as a nucleoside that mimics cellular energy depletion, thereby activating AMPK. This activation suggests a subsequent influence on AMPKβ2, given its role in the larger AMPK complex. Berberine, an alkaloid with multiple pharmacological effects, and Resveratrol, a natural phenol, both activate AMPK. This activation pathway is essential in regulating metabolic processes like glucose regulation and lipid metabolism, indicating an indirect impact on AMPKβ2.
In addition to these compounds, other chemicals like Salicylate, Thiazolidinediones (e.g., Pioglitazone), and DNP (2,4-Dinitrophenol) also play significant roles. Salicylate, through its AMPK activation, regulates insulin resistance and glucose homeostasis, implicating a possible influence on AMPKβ2. Thiazolidinediones are known for improving insulin sensitivity and glucose utilization, actions achieved partly through AMPK activation. DNP, despite its toxicity, exemplifies a response to increased cellular energy demand through its uncoupling of oxidative phosphorylation, which in turn activates AMPK. Additional compounds like Quercetin, Alpha-Lipoic Acid, Fenofibrate, and Capsaicin further extend the scope of AMPKβ2 Activators. Quercetin's antioxidant properties and Alpha-Lipoic Acid's role as an antioxidant both contribute to AMPK activation, influencing glucose and lipid metabolism. Fenofibrate's role in managing hyperlipidemia and Capsaicin's impact on energy balance and metabolism through AMPK activation are indicative of their indirect interactions with AMPKβ2.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
A biguanide used primarily for type 2 diabetes management. Metformin activates AMPK, potentially influencing AMPKβ2 by enhancing cellular glucose uptake and improving insulin sensitivity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
A nucleoside that activates AMPK. AICAR mimics cellular energy depletion, thereby potentially activating AMPKβ2 as part of the AMPK complex. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
An alkaloid with various pharmacological effects. Berberine activates AMPK, which may include indirect activation of AMPKβ2, influencing metabolic pathways like glucose regulation and lipid metabolism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
A natural phenol found in grapes and red wine. Resveratrol activates AMPK, potentially impacting AMPKβ2, and is involved in various metabolic processes including enhancing insulin sensitivity and modulating glucose and lipid metabolism. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
An active metabolite of aspirin. Salicylate can activate AMPK, potentially affecting AMPKβ2, and is involved in regulating insulin resistance and glucose homeostasis. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Used primarily in diabetes management, these compounds activate AMPK, potentially influencing AMPKβ2, and improve insulin sensitivity and glucose utilization. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $58.00 | 2 | |
A chemical that uncouples oxidative phosphorylation. While toxic and not used clinically, DNP can activate AMPK, including potentially AMPKβ2, as a response to increased cellular energy demand. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A flavonoid with antioxidant properties. Quercetin can activate AMPK, potentially affecting AMPKβ2, and influences metabolic pathways like lipid and glucose metabolism. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
An antioxidant that activates AMPK. It may indirectly influence AMPKβ2, improving glucose uptake and insulin sensitivity. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
A fibrate drug that can activate AMPK, potentially influencing AMPKβ2, and is primarily used to manage hyperlipidemia. | ||||||