αB-crystallin Inhibitors
αB-crystallin inhibitors are a class of chemical compounds that target a specific protein known as αB-crystallin. αB-crystallin is a molecular chaperone protein that is primarily found in the eye's lens, where it plays a crucial role in maintaining the transparency and structural integrity of the lens fibers. It is also found in various other tissues, including muscle, heart, and brain. The primary function of αB-crystallin is to prevent the aggregation and misfolding of other proteins, particularly those that are susceptible to structural changes due to stress or damage.
Inhibitors of αB-crystallin are designed to modulate the activity of this protein. These inhibitors can either reduce or enhance αB-crystallin's chaperone function, depending on the desired outcome. Understanding the regulation of αB-crystallin can shed light on its involvement in diseases such as cataracts, neurodegenerative disorders, and muscle-related conditions. Thus, αB-crystallin inhibitors are valuable tools in the study of protein folding, aggregation, and cellular stress responses, contributing to our knowledge of these processes in both health and disease.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to HSP90, potentially disrupting its function and affecting the stability of its client proteins, including possibly αB-crystallin. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
As a proteasome inhibitor, Bortezomib can impact protein degradation pathways, which might indirectly influence the levels of αB-crystallin in cells. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As an HDAC inhibitor, Trichostatin A alters histone acetylation, potentially impacting gene expression and indirectly affecting αB-crystallin expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
By inhibiting mTOR, Rapamycin can impact cellular growth and metabolism, potentially influencing the expression of αB-crystallin. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, a stress-activated protein kinase, potentially influencing signaling pathways that regulate αB-crystallin expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits p38 MAPK, potentially affecting stress response pathways and indirectly influencing αB-crystallin expression. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 inhibits NF-κB, potentially impacting inflammation and stress response pathways and indirectly influencing αB-crystallin expression. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
As an AMPK activator, 1,1-Dimethylbiguanide, Hydrochloride can influence cellular energy balance, potentially having an indirect effect on αB-crystallin expression. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil, a calcium channel blocker, impacts cellular calcium homeostasis, potentially influencing αB-crystallin expression. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
As a ROS scavenger, N-Acetyl-L-cysteine can neutralize reactive oxygen species, potentially influencing αB-crystallin expression under oxidative stress conditions. | ||||||