α8 Tubulin Inhibitors
α8 Tubulin Inhibitors could be conceived as a novel class of chemical compounds designed to modulate cellular processes by selectively targeting the α8 domain of tubulin. Tubulin is a key component of the cytoskeleton, and its polymerization into microtubules is critical for maintaining cell shape and facilitating intracellular transport. The α8 domain, a region within tubulin, might be crucial for the regulation of microtubule dynamics. α8 Tubulin Inhibitors, if they were to exist, could potentially exert their effects by binding selectively to this domain, thereby disrupting the normal assembly and disassembly of microtubules.
The putative mechanism of action for α8 Tubulin Inhibitors might involve interference with microtubule dynamics, impacting essential cellular processes such as mitosis and intracellular transport. By selectively targeting the α8 domain, these inhibitors could induce conformational changes in tubulin, potentially inhibiting its ability to polymerize into stable microtubules. Understanding the structure-activity relationships of α8 Tubulin Inhibitors would be essential for optimizing their selectivity and efficacy. This description underscores the importance of exploring new chemical classes to gain insights into the intricate regulation of microtubule dynamics within cells. Further research would be necessary to provide accurate and detailed information about any potential α8 Tubulin Inhibitors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This compound intercalates into DNA and inhibits RNA polymerase, potentially reducing tubulin mRNA transcription. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits the translocation step in protein synthesis on ribosomes, thus could decrease the synthesis of tubulin proteins. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR signaling which is involved in protein synthesis and cell cycle progression, affecting tubulin protein levels. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
It is incorporated into DNA and RNA, inhibits methylation, and may impact the expression of genes including tubulin. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, it changes chromatin structure and can influence gene expression patterns. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin strongly inhibits RNA polymerase II, decreasing mRNA production for tubulin and other proteins. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
It depletes guanine nucleotides, affecting RNA and DNA synthesis, which can lead to reduced tubulin expression. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin interferes with peptide bond formation on ribosomes, inhibiting protein synthesis including that of tubulin. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
By inhibiting topoisomerase I, camptothecin reduces DNA replication and transcription, potentially lowering tubulin levels. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB selectively inhibits RNA polymerase II, which could lead to decreased expression of tubulin mRNA. | ||||||