ALG-4 Inhibitors
ALG-4 inhibitors are chemical compounds that directly or indirectly influence the function of ALG-4, a protein involved in the PI3K/Akt signaling pathway. Inhibitors like Wortmannin, LY294002, Quercetin, PI-103, and PX-866 disrupt the activation of Akt by inhibiting PI3K, an upstream regulator of Akt. PI3K is a lipid kinase that phosphorylates phosphatidylinositol 4,5-bisphosphate to generate phosphatidylinositol 3,4,5-trisphosphate, a secondary messenger that activates Akt. By inhibiting PI3K, these compounds reduce the generation of phosphatidylinositol 3,4,5-trisphosphate, thereby reducing the activation of Akt. As Akt is involved in the phosphorylation and activation of ALG-4, disrupting Akt activation can lead to decreased functional activity of ALG-4.
Compounds like AKT inhibitor VIII, Perifosine, Triciribine, GSK690693, MK-2206, and API-2 directly inhibit the Akt signaling pathway. Akt, also known as protein kinase B, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration. By directly inhibiting Akt, these compounds can decrease the phosphorylation and activation of ALG-4. Furthermore, Rapamycin and PI-103 can disrupt the mTOR signaling downstream of Akt. mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility,cell survival, protein synthesis, and transcription. By inhibiting mTOR, these compounds can further decrease the activation of ALG-4. Each of these inhibitors, therefore, negatively influences the functional activity of ALG-4, either through direct inhibition of Akt, or indirect inhibition via PI3K or mTOR pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. Since PI3K is involved in many signaling pathways that can induce the phosphorylation and activation of ALG-4, the inhibition of PI3K by Wortmannin can lead to a decrease in the functional activity of ALG-4. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another PI3K inhibitor. Its inhibition of PI3K can decrease the phosphorylation and activation of ALG-4, thereby reducing its functional activity. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $208.00 $270.00 | 29 | |
AKT inhibitor VIII directly inhibits Akt, a key signaling molecule involved in the phosphorylation and activation of ALG-4. By inhibiting Akt, the inhibitor can reduce the functional activity of ALG-4. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that inhibits PI3K. Its inhibition of PI3K can lead to a decrease in the phosphorylation and activation of ALG-4, thereby reducing its functional activity. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
Perifosine is an Akt inhibitor. By inhibiting Akt, it can decrease the activation of ALG-4, leading to a reduction in its functional activity. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine is a specific Akt inhibitor. Its inhibition of Akt can lead to a decrease in the activation of ALG-4, resulting in a decrease in its functional activity. | ||||||
GSK 690693 | 937174-76-0 | sc-363280 sc-363280A | 10 mg 50 mg | $255.00 $1071.00 | 4 | |
GSK690693 is an Akt kinase inhibitor. Its inhibition of Akt can lead to a decrease in the phosphorylation and activation of ALG-4, thereby reducing its functional activity. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
MK-2206 is a highly specific Akt inhibitor. By inhibiting Akt, it can reduce the phosphorylation and activation of ALG-4, leading to a decrease in its functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. As mTOR is a downstream effector in the PI3K/Akt pathway, its inhibition can lead to a decrease in the activation of ALG-4. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $33.00 $131.00 | 3 | |
PI-103 is a potent inhibitor of both PI3K and mTOR. By inhibiting these molecules, it can reduce the phosphorylation and activation of ALG-4, thereby reducing its functional activity. | ||||||