Date published: 2026-4-20

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Akt3 Inhibitors

Akt3 inhibitors belong to a class of small organic molecules designed to selectively target and inhibit the activity of Akt3, a serine/threonine protein kinase. Akt3, also known as Protein Kinase B gamma (PKBγ), is one of three isoforms of the Akt (Protein Kinase B) family, with the other two being Akt1 and Akt2. These kinases are crucial components of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway, which plays a central role in regulating various cellular processes, including cell growth, proliferation, survival, and metabolism. Akt3, in particular, is primarily expressed in the brain and testes and is involved in processes related to neuronal development and function.The chemical class of Akt3 inhibitors is characterized by their ability to disrupt the signaling cascade initiated by Akt3 activation. Structurally, these inhibitors often feature a core scaffold that can interact with the ATP-binding site of Akt3, thus preventing the phosphorylation of downstream substrates. They may possess various chemical moieties and functional groups that enhance their binding affinity and specificity for Akt3. The development of Akt3 inhibitors has been driven by the recognition that dysregulation of the Akt3 pathway is implicated in several diseases, especially certain types of cancer.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MK-2206 dihydrochloride

1032350-13-2sc-364537
sc-364537A
5 mg
10 mg
$182.00
$332.00
67
(1)

MK-2206 is an active allosteric Akt inhibitor that specifically targets Akt1, Akt2, and AktIt is being studied in clinical trials for its potential in treating various cancers.

Triciribine

35943-35-2sc-200661
sc-200661A
1 mg
5 mg
$104.00
$141.00
14
(1)

Triciribine (CAS 35943-35-2) is a compound known for its ability to inhibit Akt3, a protein associated with cell signaling.

Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2

612847-09-3sc-202048
sc-202048A
1 mg
5 mg
$208.00
$270.00
29
(1)

Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (CAS 612847-09-3) is a compound known for its inhibition of Akt3, a protein involved in cell signaling pathways.

GSK 690693

937174-76-0sc-363280
sc-363280A
10 mg
50 mg
$255.00
$1071.00
4
(1)

GSK690693 is a small molecule inhibitor of Akt1, Akt2, and AktIt has been studied in preclinical and clinical trials for its anti-cancer activity.

Perifosine

157716-52-4sc-364571
sc-364571A
5 mg
10 mg
$188.00
$327.00
1
(2)

Perifosine, also known as KRX-0401, is an experimental drug that inhibits Akt activation. It has been investigated for its anti-cancer properties, particularly in multiple myeloma and other solid tumors.

Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2

sc-221231
2 mg
$480.00
1
(0)

Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 is a compound that effectively inhibits Akt3, a key protein involved in cell signaling pathways.

AZD5363

1143532-39-1sc-503190
5 mg
$309.00
(0)

AZD5363 is a potent and selective inhibitor of all three Akt isoforms (Akt1, Akt2, and Akt3).

AT7867

857531-00-1sc-364417
sc-364417A
10 mg
50 mg
$450.00
$1300.00
1
(0)

AT7867 is a potent inhibitor of Akt1, Akt2, and Akt3, as well as other kinases. It has been investigated for its anti-cancer properties in preclinical studies.

(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone

sc-501166
5 mg
$540.00
(0)

Ipatasertib is a selective inhibitor of Akt1, Akt2, and AktIt is being explored as a potential therapy for various cancers, including breast cancer.