Molecular structure of AT7867, CAS Number: 857531-00-1
AT7867 (CAS 857531-00-1)
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Alternate Names:
pyrazole-based inhibitor 9
Application:
AT7867 is a potent ATP-competitive inhibitor of Akt1, Akt2 and Akt3
CAS Number:
857531-00-1
Molecular Weight:
337.85
Molecular Formula:
C20H20ClN3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AT7867 is a potent ATP-competitive inhibitor of Akt1, Akt2 and Akt3 (IC50: Akt1= 32 nM, Akt2 = 17 nM and Akt3 = 47 nM). AT7867 also inhibits structurally related AGC kinases p70S6K and PKA, and shows ATP-competitive activity to Akt2 with a Ki of 18 nM. AT7867 exhibits antiproliferation in cell lines with PTEN or PIK3CA mutations, and suppresses the cell growth of U87MG, PC-3 and DU145 cells. AT7867 suppresses Akt activity by inhibiting phosphorylation of GSK3β in human tumor cells, and induces the phosphorylation of the following Akt direct substrates including proapoptotic transcription factors FKHR (FoxO1a), FKHRL1 (FoxO3a) and the downstream target S6RP in U87MG cells.
Inhibitor of:
Akt1, Akt2, Akt3, p70 S6 Kinase, and PKA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AT7867, 10 mg | sc-364417 | 10 mg | $450.00 | |||
AT7867, 50 mg | sc-364417A | 50 mg | $1300.00 |