Molecular structure of Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2
Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2
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Application:
Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 is a cell-permeable and water soluble analog of Akt Inhibitor VIII
Molecular Weight:
763.2
Molecular Formula:
C40H43N7O2•3HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 is a highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (sc-202048) that acts as a plecktrin homology (PH)-domain dependent, non-ATP competitive and an allosteric inhibitor of Akt1/2 (IC50 = 560 nM, 390 nM and 7.8 µM in in vitro kinase assay; 526 nM, 730 nM and > 10 µM in LNCaP cells for Akt1, Akt2 and Akt3, respectively) with ~ 80-fold greater selectivity over PKA, PKC and SGK (IC50 > 50 µM). One of the compounds potent regioisomers (C7-substituted) is shown to enhance induced caspase-3 activity in several tumor cells.
Inhibitor of:
Akt1, Akt2, Akt3, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2, 2 mg | sc-221231 | 2 mg | $480.00 |