AKR7A5 Activators
AKR7A5 Activators, a class of chemical compounds, play a crucial role in regulating the activity of the enzyme aldo-keto reductase 7A5 (AKR7A5). These activators are primarily characterized by their ability to modulate the enzymatic function of AKR7A5, a member of the aldo-keto reductase superfamily. This class of molecules typically acts as allosteric effectors, influencing the enzyme's kinetics and substrate specificity. AKR7A5 itself is an NADPH-dependent reductase enzyme that participates in various metabolic and detoxification pathways. Its broad substrate specificity makes it a key player in the biotransformation of endogenous and exogenous compounds, ranging from xenobiotics to endogenous carbonyl compounds. AKR7A5 Activators, through their interaction with the enzyme, can fine-tune its activity, which has implications in cellular homeostasis and the metabolism of a wide range of compounds.
These activators are often researched in the context of understanding the biochemical and physiological significance of AKR7A5 in cellular processes. By influencing the enzyme's activity, they can help elucidate the regulatory mechanisms and functional outcomes of AKR7A5 in various tissues and organisms. The study of AKR7A5 Activators has potential applications in fields such as toxicology, drug metabolism, and chemical biology, where a detailed understanding of the enzyme's modulation can shed light on the metabolism of drugs and environmental toxins.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $66.00 | 4 | |
tBHQ is recognized for its role in activating the Nrf2 pathway, which, in turn, enhances the expression of AKR7A5 and other detoxification enzymes. It is widely used as a food preservative. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
NAC, by serving as a precursor to glutathione, indirectly promotes the activation of AKR7A5, an enzyme involved in detoxification pathways. NAC is used in various clinical applications, including detoxification support. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
A known inhibitor of cytochrome P450 enzymes, ketoconazole may indirectly activate AKR7A5 by affecting the metabolism of AKR7A5 substrates, potentially influencing its enzymatic activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This epigenetic modulator can indirectly activate AKR7A5 by inhibiting DNA methyltransferases, leading to changes in gene expression, including the expression of AKR7A5. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Vitamin C acts as an antioxidant, directly activating cellular responses to oxidative stress. This can indirectly activate detoxification pathways, including those involving AKR7A5 activation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an activator of AMP-activated protein kinase (AMPK), which can directly activate energy metabolism and potentially promote AKR7A5 activation if it plays a role in energy-related pathways. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate, a PPAR agonist, is used to treat hyperlipidemia and may directly activate AKR7A5 activity if the enzyme is associated with lipid metabolism pathways activated by PPARs. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin is an AMPK activator and a common agent in research for type 2 diabetes. It can directly activate AKR7A5 activity if the enzyme is involved in energy metabolism and cellular pathways regulated by AMPK. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, an AMPK activator, can potentially directly activate AKR7A5 activity if the enzyme participates in energy metabolism and cellular pathways regulated by AMPK. It is commonly found in red wine and various plants and is associated with health benefits. | ||||||