AKR7A5 Inhibitors
AKR7A5 inhibitors belong to a class of chemical compounds specifically designed to target and modulate the activity of the enzyme AKR7A5. AKR7A5, short for Aldo-Keto Reductase Family 7 Member A5, is a member of the aldo-keto reductase (AKR) enzyme superfamily, which plays a crucial role in cellular metabolism and detoxification processes. AKR7A5, in particular, is responsible for the reduction of aldehydes and ketones, making it an essential component of the cellular detoxification system. Inhibition of AKR7A5 is of interest in various scientific and biomedical contexts, as it may lead to a better understanding of its role in cellular processes and potential implications for drug development.
AKR7A5 inhibitors are designed to selectively bind to the active site of the AKR7A5 enzyme, thereby blocking its enzymatic activity. This inhibition can be achieved through various mechanisms, such as competitive binding or allosteric modulation. By inhibiting AKR7A5, these compounds can affect the metabolic pathways that involve aldehydes and ketones, potentially influencing the cellular response to oxidative stress and toxicants.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can inhibit aldehyde dehydrogenase, leading to an accumulation of aldehydes which could saturate AKR7A5, thereby reducing its catalytic efficiency. | ||||||
Aminoglutethimide | 125-84-8 | sc-207280 sc-207280A sc-207280B sc-207280C | 1 g 5 g 25 g 100 g | $42.00 $146.00 $541.00 $2060.00 | 2 | |
Aminoglutethimide inhibits the synthesis of steroid hormones, which could alter the metabolism and availability of substrates for AKR7A5. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin, a COX inhibitor, may alter prostaglandin levels, which can affect the cellular environment and indirectly influence AKR7A5 activity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate may interfere with folate metabolism, influencing the cellular redox state and potentially affecting AKR7A5 function. | ||||||
Fomepizole | 7554-65-6 | sc-252838 | 1 g | $75.00 | 1 | |
Fomepizole inhibits alcohol dehydrogenase and could lead to an increased aldehyde substrate presence, possibly overloading AKR7A5's capacity. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $26.00 $36.00 $47.00 $136.00 $455.00 | 3 | |
Vitamin K3 undergoes redox cycling and can deplete cellular reducing agents such as NADPH, potentially impairing AKR7A5's reducing capability. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz modulates various cytoprotective enzymes and can change the redox state of a cell, which could indirectly inhibit AKR7A5 by altering its substrate pool. | ||||||
Ritonavir | 155213-67-5 | sc-208310 | 10 mg | $124.00 | 7 | |
Ritonavir is known to inhibit various cytochrome P450 enzymes, which could lead to changes in the metabolism of compounds relevant to AKR7A5. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid sodium salt affects hepatic metabolism and could influence the cellular redox state, indirectly modifying AKR7A5 activity. | ||||||
Tolfenamic Acid | 13710-19-5 | sc-204918 sc-204918A | 5 g 25 g | $69.00 $312.00 | ||
Tolfenamic acid influences the expression of various proteins through its effect on transcription factors and may affect AKR7A5 indirectly in this manner. | ||||||