Disulfiram CAS: 97-77-8
MF: C10H20N2S4
MW: 296.54
An ALDH and tumor cell growth inhibitor.

Disulfiram (CAS 97-77-8)

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Disulfiram is rated 5.0 out of 5 by 1.
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Nomi alternativi: Tetraethylthiuram disulfide
Applicazione: Disulfiram is an ALDH and tumor cell growth inhibitor
Numero CAS: 97-77-8
Purezza: ≥97%
Peso molecolare: 296.54
Formula molecolare: C10H20N2S4
Informazioni supplementari: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

Disulfiram is a DNA demethylating agent and DIG1 inducer which inhibits prostate cancer cell growth by inhibition of DNA methyltransferase (Dnmt). In addition, studies indicate that disulfiram inhibits aldehyde dehydrogenase (ALDH) resulting in the accumulation of acetaldehyde upon ethanol ingestion. Alternate studies show that disulfiram also inhibits dopamine β-hydroxylase (DBH), an enzyme important in converting dopamine to norepinephrine in noradrenergic neurons. Futhermore, disulfiram can reduce toxicity and carcinogenesis by inhibiting the cytochrome P450IIE1 (CYP2E1). It has been reported that disulfiram can also inhibit tumor cell growth via binding to cellular copper, which inhibits proteosome activity and induces apoptosis. Disulfiram is an inhibitor of ADH and V-ATPase.


Referenze

1. Brady, J.F., et al. 1991. Toxicol. Appl. Pharmacol. 108: 366-373. PMID: 1850173
2. Schroeder, J.P., et al. 2010. Neuropsychopharmacology. 35: 2440-2449. PMID: 20736996
3. Lin, J., et al. 2010. Prostate. [Epub ahead of print]. PMID: 20809552
4. Wang, F., et al. 2011. Cancer Lett. 300: 87-95. PMID: 21035945

Stato fisico :
Solid
Solubilità :
Soluble in water (4 mg/l at 25° C), acohol (38.2 mg/ml), ether (71.4 mg/ml), chloroform, and acetonitrile.
CONSERVAZIONE :
Store at room temperature
Punto di scioglimento :
69-71° C (lit.)
Punto di ebollizione :
117.2° C at 17 mmHg
Densità :
1.3 g/cm3
Indice di rifrazione :
n20D 1.62 (Predicted)
IC50 :
MCF7: IC50 = 0.1 µM (human); T47D: IC50 = 0.17 µM (human); MDA-MB-231: IC50 = 0.32 µM (human); Adenosine A3-R: IC50 = 0.36 µM (human); D3DR: IC50 = 1.08 µM (human)
Ki Data :
Adenosine A3-R: Ki= 0.2 µM (human); D3DR: Ki= 0.37 µM (human); CKR-2B: Ki= 0.95 µM (human); D1DR: Ki= 1.08 µM (human); D4DR: Ki= 1.11 µM (human)
Valori pK :
pKb: 0.86 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
JO1225000
PubChem CID :
Indice Merck :
14: 3364
Numero MDL :
MFCD00009048
Numero EC :
202-607-8
Registro Beilstein :
1712560
SMILES :
CCN(CC)C(=S)SSC(=S)N(CC)CC

Download SDS (MSDS)

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Disulfiram (CAS 97-77-8)  Citazioni prodotti

Vedi quanti altri hanno usato Disulfiram (CAS 97-77-8). Clicca sulla voce per laccesso a PubMed .

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PMID: # 26577527  Mali, VR. et al. 2016. Cell. Signal. 28: 1-6.

PMID: # 33009395  Nat Commun. 4958.

PMID: # 27203215  Oncotarget. 82200-82212.

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