AF-4 Inhibitors
The AF-4 inhibitor is a chemically distinct class of compounds that plays a crucial role in regulating specific biological processes within the human body. These inhibitors are designed to target and modulate the activity of AF-4, a transcription elongation factor that is part of the super elongation complex (SEC). Transcription elongation is a fundamental step in gene expression, where the genetic information stored in DNA is transcribed into RNA for subsequent protein synthesis. AF-4, along with other SEC components, is involved in the regulation of RNA polymerase II (RNAPII) activity, which is responsible for synthesizing most cellular RNAs, including mRNAs.
AF-4 inhibitors are designed to interact with AF-4 protein, either directly or indirectly, to disrupt its function. This disruption can lead to alterations in RNAPII activity, affecting the transcription process. AF-4 itself is known to be associated with various cancers, particularly in fusion with other genes, leading to abnormal gene expression and cellular transformation. AF-4 inhibitors have emerged as potential tools in the field of molecular biology and research, enabling scientists to study the role of AF-4 in gene regulation and its implications in various cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
WZ8040 | 1214265-57-2 | sc-364656 sc-364656A | 5 mg 10 mg | $255.00 $480.00 | ||
WZ811 is a small molecule that acts as an allosteric modulator of CXCR4, a chemokine receptor that AF4 can interact with as part of the signaling pathways involved in leukemic cells. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is upstream of ERK1/2 in the MAPK/ERK pathway. AF4 may be regulated by this pathway, and inhibiting MEK can alter AF4 function indirectly. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of both MEK1 and MEK2, which can influence the MAPK/ERK pathway and consequently modulate the molecular functions of AF4. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of JNK, which indirectly affects the signaling cascades that could modulate AF4 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter PI3K/AKT signaling, a pathway that can regulate a variety of proteins including AF4. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can disrupt mTOR signaling pathways, potentially affecting AF4 activity or its protein interactions indirectly. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor, similar to LY294002, and can impact the PI3K/AKT pathway, thereby indirectly modulating AF4-related processes. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that, while not specific, can affect multiple signaling pathways, potentially altering AF4 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor and can influence pathways that might interact with or regulate AF4. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib is a tyrosine kinase inhibitor that, while primarily used for BCR-ABL, can also affect other kinases and signaling pathways that could indirectly influence AF4 function. | ||||||