ADMP Activators
ADMP, or Anti-Dorsalizing Morphogenetic Protein, is a member of the TGF-β (Transforming Growth Factor-beta) superfamily of secreted signaling molecules, which play critical roles in development and homeostasis in multicellular organisms. It is encoded by the gene ADMP. This protein functions as a morphogen, a type of substance that can dictate the fate of cells in a concentration-dependent manner during embryonic development.
ADMP is particularly important in early vertebrate embryogenesis, where it has a crucial role in the establishment of the dorsoventral axis, a fundamental body plan feature that distinguishes the back (dorsal) from the belly (ventral) side of the organism. It operates by counterbalancing the effects of other TGF-β family members, such as BMPs (Bone Morphogenetic Proteins), that promote dorsal cell fates. By doing so, ADMP helps to refine and maintain the correct distribution of cell types along the dorsoventral axis.The mechanism of ADMP action involves its interaction with specific receptors on the cell surface, leading to the activation of SMAD proteins, which then translocate to the nucleus and regulate the expression of target genes. This cascade is part of intricate regulatory networks that control cell differentiation, proliferation, and apoptosis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thymosin β4 | 77591-33-4 | sc-396076 sc-396076A | 1 mg 100 mg | $134.00 $7140.00 | ||
TGF-beta1 is a well-known activator of the TGF-beta signaling pathway, which can potentially upregulate ADMP expression or enhance its biological activity by influencing the cellular environment and related signaling cascades. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $107.00 $156.00 | 4 | |
LY364947 is a potent inhibitor of TGF-beta type I receptor kinase, which could indirectly affect ADMP activity by altering TGF-beta signaling dynamics, potentially leading to compensatory mechanisms that modulate ADMP function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is a selective inhibitor of TGF-beta type I receptor ALK5 kinase, ALK4, and ALK7, which may indirectly influence ADMP activity by disrupting TGF-beta signaling and possibly triggering alternative regulatory mechanisms. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
A83-01 is an inhibitor of TGF-beta type I receptor ALK5 kinase, ALK4, and ALK7, similar to SB431542, and can indirectly impact ADMP activity by modulating the TGF-beta signaling pathway. | ||||||
GW788388 | 452342-67-5 | sc-363544 sc-363544A | 5 mg 25 mg | $95.00 $384.00 | ||
GW788388 is a potent inhibitor of TGF-beta type I receptor kinase ALK5 and ALK4, potentially affecting ADMP activity by altering TGF-beta/Activin signaling, which might influence ADMP regulation. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $77.00 $153.00 $219.00 $663.00 $1248.00 $4382.00 $7850.00 | 8 | |
RepSox is a selective inhibitor of the TGF-beta type I receptor ALK5 kinase, potentially affecting ADMP activity by modulating TGF-beta signaling, which could impact ADMP's functional dynamics in the cell. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $213.00 $359.00 | 3 | |
LY2157299, a selective inhibitor of TGF-beta type I receptor kinase ALK5, might indirectly influence ADMP activity by altering the dynamics of TGF-beta signaling, which could lead to changes in ADMP-related processes. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $88.00 | 3 | |
SD-208 is a TGF-betaRI kinase inhibitor, potentially affecting ADMP activity by modulating the TGF-beta signaling pathway, thereby possibly impacting the regulatory mechanisms associated with ADMP. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
EW-7197 is a potent inhibitor of TGF-beta type I receptor kinase ALK5, potentially influencing ADMP activity by altering the TGF-beta signaling pathway, which might affect ADMP's role in the cell. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
Dorsomorphin is an inhibitor of BMP signaling, which is closely related to TGF-beta signaling. It might | ||||||