ADAM6A Activators
ADAM6A Activators are chemical compounds that either directly or indirectly enhance the functional activity of ADAM6A. BB-94 is a selective direct activator of ADAM6A that induces ectodomain shedding of critical substrates such as pro-HBEGF by binding and activating its protease domain. Other indirect ADAM6A activators influence inhibitory signaling mechanisms. LY333531 inhibits ADAM17 and could thus relieve competitive inhibition of ADAM6A for shared substrates. Ro-31-8220 and Apicularen A are PKC and PKMζ inhibitors, respectively, suggesting they may disinhibit ADAM6A from phosphorylation-dependent suppression.
Additional indirect activators modulate pathways inhibiting ADAM6A. SB431542 inhibits TGF-β signaling to counter downstream repression of ADAM6A expression. VX-745 and Nsc-87877 block the IRAK and IKK kinases of the NF-κB pathway, preventing ADAM6A transcriptional inhibition. Piceatannol may mitigate inhibitory phosphorylation restraints, while LY294002 interferes with PI3K pathways modulating substrate presentation and ADAM6A suppression. Collectively, these ADAM6A Activators-whether directly targeting ADAM6A or influencing inhibitory mechanisms-work to optimize ADAM6A protease activity and signaling output without requiring overexpression.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
A selective ADAM6A activator that induces ectodomain shedding of critical ADAM6A substrates like pro-HBEGF by directly binding and activating the protease domain of ADAM6A, thereby increasing its functional signaling. | ||||||
LY-333,531 Hydrochloride | 169939-93-9 | sc-364215 sc-364215A | 1 mg 5 mg | $94.00 $287.00 | 6 | |
A selective TACE/ADAM17 inhibitor that may indirectly activate ADAM6A signaling pathways by relieving competitive inhibition by ADAM17 for shared substrates. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
An irreversible PKC inhibitor that could hypothetically enhance ADAM6A activity by preventing phosphorylation-dependent suppression of its protease function by PKC. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
A selective inhibitor of TGF-β type 1 receptor activin receptor-like kinase (ALK) 5 that may indirectly activate ADAM6A by interfering with downstream TGF-β pathway inhibition of ADAM6A expression. | ||||||
VX 745 | 209410-46-8 | sc-361401 sc-361401A | 10 mg 50 mg | $183.00 $842.00 | 4 | |
An IRAK1/4 inhibitor that may potentiate ADAM6A signaling by preventing NF-κB pathway inhibition of ADAM6A transcription mediated by IRAK kinases. | ||||||
NSC 87877 | 56990-57-9 | sc-204139 | 50 mg | $137.00 | 12 | |
An IKKβ kinase inhibitor that could hypothetically enhance ADAM6A activity by blocking NF-κB pathway inhibition of ADAM6A downstream of IKKβ. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
A broad tyrosine or serine/threonine kinase inhibitor that may relieve inhibitory phosphorylation restraints on ADAM6A to boost its substrate cleavage activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A selective PI3K inhibitor that may indirectly activate ADAM6A by interfering with PI3K pathways involved in substrate presentation and suppression of ADAM6A function. | ||||||