ADAM38 Activators
Chemical activators of ADAM20 include a variety of compounds that engage with the enzyme to enhance its proteolytic activity. Zinc acetate contributes to this process by providing zinc ions that bind to the active site of ADAM20, maintaining structural integrity vital for its catalytic function. Similarly, manganese(II) sulfate supplies manganese ions which act as cofactors essential for the protease's enzymatic action. Copper(II) sulfate's contribution is through copper ions interacting with the metalloprotease domain of ADAM20, which is crucial for its function. Magnesium chloride and calcium chloride also participate by providing magnesium and calcium ions, respectively, which help stabilize the enzyme's structure and ensure proper substrate binding.
Further activation of ADAM20 is facilitated by compounds that induce phosphorylation or other post-translational modifications. Sodium orthovanadate activates ADAM20 by inhibiting protein tyrosine phosphatases, leading to a higher phosphorylation state of proteins that regulate the metallopeptidase. Phorbol 12-myristate (PMA) activates protein kinase C, which in turn can phosphorylate ADAM20, while forskolin stimulates adenylate cyclase, increasing cAMP levels and activating protein kinase A, which may also target ADAM20 for phosphorylation. Hydrogen peroxide triggers oxidative mechanisms that can induce changes enhancing ADAM20's activity. Sodium nitroprusside, which releases nitric oxide, can lead to S-nitrosylation of ADAM20, modifying its interaction with substrates or regulatory proteins. Cobalt(II) chloride and nickel(II) sulfate can activate ADAM20 by providing cobalt and nickel ions, respectively, that may serve as alternative cofactors or bind to the metalloprotease domain, potentially boosting the enzyme's proteolytic efficiency.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can activate a disintegrin and metallopeptidase domain 20 by binding to the enzyme's active site, thus assisting in maintaining its structural integrity essential for catalytic activity. | ||||||
Manganese(II) sulfate monohydrate | 10034-96-5 | sc-203130 sc-203130A | 100 g 500 g | $41.00 $107.00 | ||
Manganese ions serve as cofactors that can activate ADAM20 by enhancing the protein's catalytic action, as metalloprotease enzymes like ADAM20 require such metal ions for their enzymatic activity. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper ions can directly activate ADAM20 by interacting with its metalloprotease domain, which is critical for the protein's enzymatic function. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Magnesium ions can activate ADAM20 by stabilizing the structure of the enzyme, which is necessary for its activity since proper conformation is required for the binding and processing of substrates. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions can activate ADAM20 as they play a role in stabilizing the protein's structure and function, particularly in the context of enzymatic activity where substrate binding is essential. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate can activate ADAM20 by inhibiting protein tyrosine phosphatases, which may result in a heightened phosphorylation state of proteins that interact with or regulate the activity of ADAM20. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C which can then phosphorylate and activate ADAM20, as phosphorylation is a common mechanism of activation for membrane-bound metalloproteases. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide can activate ADAM20 through oxidative mechanisms, potentially inducing conformational changes or oxidative modifications that enhance the protein's catalytic activity. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Sodium nitroprusside can release nitric oxide, which may lead to the S-nitrosylation of ADAM20. This post-translational modification can activate the protein by altering its interaction with substrates or regulatory proteins. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Cobalt ions can activate ADAM20 by binding to its active site, potentially acting as alternative cofactors for the metalloenzyme, thereby influencing its proteolytic function. | ||||||