ACO2 Activators
ACO2 activators, also known as Aconitase 2 activators, belong to a class of chemical compounds that play a pivotal role in the regulation of cellular metabolism and energy production. Aconitase 2 (ACO2) is a mitochondrial enzyme that primarily functions as a key component of the tricarboxylic acid (TCA) cycle, also known as the citric acid cycle or Krebs cycle. This cycle is a fundamental metabolic pathway that takes place within the mitochondria, the energy-producing organelles of eukaryotic cells. ACO2 is essential for catalyzing the conversion of citrate to isocitrate in the TCA cycle, which is a critical step for generating energy in the form of adenosine triphosphate (ATP). ACO2 activators are chemical compounds that enhance the enzymatic activity of ACO2, thereby influencing the rate of the TCA cycle and, consequently, the overall cellular energy production.
The activation of ACO2 by these compounds is of significant interest in the fields of biochemistry and cell biology as it can impact various cellular processes beyond energy production. ACO2 activators have the potential to influence the production of important metabolic intermediates that serve as precursors for the synthesis of various biomolecules, such as amino acids, nucleotides, and lipids. Moreover, these activators may contribute to the regulation of reactive oxygen species (ROS) levels within mitochondria, as ACO2 has been implicated in ROS homeostasis
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $50.00 $110.00 $145.00 $248.00 $598.00 | 1 | |
Citric acid, as a substrate for ACO2, can increase the enzyme's activity by increasing substrate availability, thereby enhancing the Krebs cycle efficiency. | ||||||
NADH disodium salt | 606-68-8 | sc-205762 sc-205762A | 500 mg 1 g | $91.00 $127.00 | 3 | |
NADH, as a key electron donor in the mitochondrial electron transport chain, can influence the redox state of the cell, which in turn may indirectly affect ACO2 activity by altering the mitochondrial environment. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions, released from calcium chloride, can modulate mitochondrial metabolism and thus may indirectly influence ACO2 activity by affecting mitochondrial enzyme functions. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
Alpha-Ketoglutarate, another Krebs cycle intermediate, can affect the cycle's balance, indirectly influencing ACO2 activity through alterations in substrate availability and cycle efficiency. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $45.00 $75.00 $133.00 | ||
As a component of the Krebs cycle, succinic acid can influence ACO2 activity indirectly by modulating the cycle's dynamics and interconversion of metabolites. | ||||||
Fumaric acid | 110-17-8 | sc-250031 sc-250031A sc-250031B sc-250031C | 25 g 100 g 500 g 2.5 kg | $43.00 $57.00 $114.00 $228.00 | ||
Fumaric acid, being part of the Krebs cycle, can impact ACO2 indirectly by affecting the equilibrium and flow of cycle intermediates. | ||||||
Oxaloacetic Acid | 328-42-7 | sc-279934 sc-279934A sc-279934B | 25 g 100 g 1 kg | $306.00 $963.00 $7980.00 | 1 | |
Oxaloacetic acid, as a key metabolite in the Krebs cycle, can influence ACO2 activity indirectly by affecting substrate availability and cycle progression. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10, involved in the electron transport chain, can indirectly affect ACO2 by altering the mitochondrial membrane potential and overall metabolic state. | ||||||
L-Glutamine | 56-85-9 | sc-391013 sc-391013C sc-391013A sc-391013D sc-391013B | 100 g 250 g 1 kg 5 kg 10 kg | $37.00 $47.00 $99.00 $379.00 $733.00 | 2 | |
L-Glutamine, through its role in anaplerotic reactions, can indirectly influence ACO2 activity by contributing to the pool of Krebs cycle intermediates. | ||||||