ABHD5 Activators
ABHD5 activators constitute a class of chemicals that indirectly stimulate the enzymatic activity of ABHD5 or modulate the pathways in which ABHD5 is involved. These activators work through a variety of mechanisms, primarily by upregulating the processes of lipid metabolism. For instance, some activators work by increasing intracellular levels of cAMP, a secondary messenger that accelerates the breakdown of fats through lipolysis, thereby potentially enhancing the functional role of ABHD5 in lipid droplet mobilization.
Others function as agonists for peroxisome proliferator-activated receptors (PPARs), which are nuclear receptor proteins that regulate the expression of genes involved in the storage and metabolism of fats. Activation of PPARs can lead to increased expression of ABHD5 or related lipases, thus boosting the lipolytic capacity of cells. Additionally, compounds that activate AMP-activated protein kinase (AMPK) can initiate a cascade of events leading to the phosphorylation and activation of enzymes in lipid catabolism, which may include enzymes associated with ABHD5's activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. Elevated cAMP enhances lipolysis, potentially upregulating ABHD5 activity. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
PPARγ agonist that modulates transcription of genes involved in lipid metabolism, possibly influencing ABHD5 expression. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AMPK activator that may enhance the phosphorylation of lipolytic enzymes, indirectly affecting ABHD5's role in lipid hydrolysis. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
PPAR agonist with potential to upregulate lipid metabolism genes, possibly affecting ABHD5 activity. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
PPARδ agonist that may increase expression of genes involved in fatty acid oxidation, potentially upregulating ABHD5. | ||||||
L-165041 | 79558-09-1 | sc-203094 | 5 mg | $156.00 | ||
PPARδ agonist that could stimulate transcriptional activity of lipid metabolism genes, potentially affecting ABHD5. | ||||||
CL 316243 disodium salt | 151126-84-0 | sc-203895 sc-203895A | 10 mg 50 mg | $590.00 $1566.00 | 15 | |
Selective β3-adrenergic receptor agonist that can induce lipolysis and might influence ABHD5 activity indirectly. | ||||||
Ciglitazone | 74772-77-3 | sc-200902 sc-200902A | 5 mg 25 mg | $104.00 $428.00 | 10 | |
PPARγ agonist that could regulate lipid metabolism at the transcriptional level, potentially influencing ABHD5. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Another PPARγ agonist that can modulate lipid metabolism, potentially affecting ABHD5. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
SIRT1 activator that may enhance lipid metabolism, indirectly affecting ABHD5 activity. | ||||||