Molecular structure of CL 316243 disodium salt, CAS Number: 151126-84-0
CL 316243 disodium salt (CAS 151126-84-0)
See product citations (15)
Alternate Names:
CL 316243 disodium salt is also known as HP 186.
Application:
CL 316243 disodium salt is a highly selective, thermogenic β3-adrenoceptor agonist and anti-obesity agent.
CAS Number:
151126-84-0
Purity:
≥98%
Molecular Weight:
465.79
Molecular Formula:
C20H18ClNO7•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CL 316243 disodium salt is a highly selective β3-adrenoceptor agonist and anti-obesity agent that is >10,000-fold selective over β1 and β2. It causes a rapid decrease in blood glucose level in mice and has been used to study the induction of brown adipocytes and to increase thermogenesis in a mouse model of dietary obesity. CL 316243 disodium salt is also known as HP 186, 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt, and Disodium 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate.
CL 316243 disodium salt (CAS 151126-84-0) References
- Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes. | Himms-Hagen, J., et al. 2000. Am J Physiol Cell Physiol. 279: C670-81. PMID: 10942717
- Efficacy of the beta3-adrenergic receptor agonist CL-316243 on experimental bladder hyperreflexia and detrusor instability in the rat. | Woods, M., et al. 2001. J Urol. 166: 1142-7. PMID: 11490313
- Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent. | Bloom, JD., et al. 1992. J Med Chem. 35: 3081-4. PMID: 1354264
- The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. | Baker, JG. 2005. Br J Pharmacol. 144: 317-22. PMID: 15655528
- The effects of beta(3)-adrenoceptor agonist CL-316,243 on adiponectin, adiponectin receptors and tumor necrosis factor-alpha expressions in adipose tissues of obese diabetic KKAy mice. | Fu, L., et al. 2008. Eur J Pharmacol. 584: 202-6. PMID: 18304529
- Influence of potent and selective beta-adrenoceptor agonist, CL 316243, on the contractile response of non-pregnant human myometrium. | Pedzinska-Betiuk, A., et al. 2008. J Physiol Pharmacol. 59 Suppl 9: 43-54. PMID: 19261970
- Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in mice. | MacPherson, RE., et al. 2014. Am J Physiol Endocrinol Metab. 307: E563-70. PMID: 25096179
- PGRMC2 is an intracellular haem chaperone critical for adipocyte function. | Galmozzi, A., et al. 2019. Nature. 576: 138-142. PMID: 31748741
- Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats. | Himms-Hagen, J., et al. 1994. Am J Physiol. 266: R1371-82. PMID: 7910436
- Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist, in yellow KK mice. | Yoshida, T., et al. 1994. Life Sci. 54: 491-8. PMID: 8309351
- Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats. | Ghorbani, M. and Himms-Hagen, J. 1997. Int J Obes Relat Metab Disord. 21: 465-75. PMID: 9192230
- CL-316,243, a beta3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese rats. | de Souza, CJ., et al. 1997. Diabetes. 46: 1257-63. PMID: 9231648
- SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis. | Berkhout, TA., et al. 1997. Atherosclerosis. 133: 203-12. PMID: 9298680
- Mechanisms of the antidiabetic effects of the beta 3-adrenergic agonist CL-316243 in obese Zucker-ZDF rats. | Liu, X., et al. 1998. Am J Physiol. 274: R1212-9. PMID: 9644032
- Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. | Guerra, C., et al. 1998. J Clin Invest. 102: 412-20. PMID: 9664083
Inhibitor of:
ABHD15, and Adipogenin.Activator of:
ABHD5, beta3-AR, GS2, LSDP5, PNPLA7, PRDM16, and ZAG.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CL 316243 disodium salt, 10 mg | sc-203895 | 10 mg | $510.00 | |||
CL 316243 disodium salt, 50 mg | sc-203895A | 50 mg | $1535.00 |