A530099J19Rik Activators
Chemical activators of G protein-coupled receptor 141B (GPR141B) include a range of compounds that stimulate various receptors, leading to downstream signaling events that result in the activation of GPR141B. Isoproterenol, a synthetic catecholamine, engages adrenergic receptors, which are known to interact with GPR141B through G protein signaling pathways. This interaction typically results in an elevation of intracellular cyclic AMP, a secondary messenger crucial for GPR141B activation. Similarly, epinephrine and norepinephrine, both endogenous catecholamines, bind to adrenergic receptors, triggering a cascade of G protein-mediated events that elevate cyclic AMP and activate GPR141B. Dopamine, another neurotransmitter, activates dopamine receptors and, through G protein signaling, increases cyclic AMP, subsequently activating GPR141B.
Furthermore, histamine, which acts on histamine receptors, and acetylcholine, acting through muscarinic receptors, can both stimulate G protein-mediated pathways, influencing the levels of intracellular calcium and cyclic AMP. These changes in cellular signaling molecules are vital for the activation of GPR141B. Serotonin, engaging serotonin receptors, and angiotensin II, interacting with angiotensin receptors, both initiate G protein signaling that also leads to increased cyclic AMP or calcium levels, contributing to GPR141B activation. Glucagon and adenosine, through their respective receptors, further amplify cyclic AMP production. This common signaling molecule is again linked to the activation of GPR141B. Lastly, oxytocin and bradykinin, via their own specific receptors, trigger G protein-coupled signaling pathways that culminate in increased intracellular calcium levels, a key step in the functional activation of GPR141B. Each of these chemicals, through their unique receptor interactions, converges on the pivotal signaling pathways that promote the activation of GPR141B.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates adrenergic receptors, which can lead to the activation of G protein-coupled receptor 141B (GPR141B) through G protein signaling pathways, ultimately resulting in increased intracellular cyclic AMP and downstream signaling events. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to and activates adrenergic receptors that can couple to GPR141B, stimulating G protein-mediated signaling cascades that increase intracellular cyclic AMP levels, thereby promoting the activation of GPR141B. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine is an endogenous neurotransmitter that activates adrenergic receptors which may couple to GPR141B, leading to G protein activation, an increase in cyclic AMP, and subsequent activation of GPR141B. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine acts on dopamine receptors that can engage G protein signaling pathways linked to GPR141B, resulting in increased cyclic AMP and the activation of GPR141B. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine interacts with histamine receptors that can be associated with GPR141B activation through G protein-mediated signaling, influencing intracellular calcium levels and cyclic AMP, which contribute to activating GPR141B. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $118.00 $187.00 | 15 | |
Serotonin engages serotonin receptors, which can lead to G protein activation and increased cyclic AMP or calcium signaling, both of which are necessary for GPR141B activation. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II, through its interaction with angiotensin receptors, can activate G proteins and signaling pathways that increase intracellular calcium, which can contribute to the activation of GPR141B. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine activates adenosine receptors, which can increase intracellular cyclic AMP through G protein signaling, thereby activating GPR141B. | ||||||
Oxytocin acetate salt | 50-56-6 | sc-279938 sc-279938A sc-279938B sc-279938C sc-279938D sc-279938E | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $60.00 $180.00 $337.00 $663.00 $969.00 $1836.00 | 4 | |
Oxytocin binds to oxytocin receptors that can activate G protein-coupled signaling pathways, increasing intracellular calcium and potentially activating GPR141B. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates bradykinin receptors, which can lead to G protein-mediated signaling cascades involving increased intracellular calcium and the subsequent activation of GPR141B. | ||||||