KIR Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $46.00 $61.00 $117.00 $173.00 $530.00 | 36 | |
Glyburide, a sulfonylurea derivative, acts as a KIR by selectively binding to ATP-sensitive potassium channels, leading to channel closure and subsequent depolarization of the cell membrane. This interaction triggers a cascade of intracellular events, including increased calcium influx and enhanced insulin secretion. Its unique molecular conformation allows for specific interactions with channel subunits, influencing gating kinetics and modulating cellular excitability in distinct physiological contexts. | ||||||
Glimepiride | 93479-97-1 | sc-203058 sc-203058A | 500 mg 1 g | $101.00 $148.00 | 1 | |
Glimepiride, a sulfonylurea compound, functions as a KIR by engaging with ATP-sensitive potassium channels, resulting in their inhibition. This binding alters the channel's conformational dynamics, promoting membrane depolarization and facilitating calcium entry. The compound's structural features enable it to interact with specific amino acid residues within the channel, thereby fine-tuning the kinetics of channel opening and closing, which impacts cellular signaling pathways and excitability. | ||||||
5-Hydroxydecanoate sodium salt | 71186-53-3 | sc-200992 sc-200992A | 100 mg 500 mg | $89.00 $339.00 | 7 | |
5-Hydroxydecanoate sodium salt acts as a KIR by modulating the activity of potassium channels through its unique interaction with lipid bilayers. Its hydrophilic and hydrophobic regions allow it to integrate into membrane structures, influencing channel permeability and ion flow. This compound exhibits distinct reaction kinetics, promoting a dynamic equilibrium that affects channel gating mechanisms, ultimately altering cellular excitability and ion homeostasis. | ||||||
U-37883A | 57568-80-6 | sc-201001 sc-201001A | 5 mg 25 mg | $81.00 $385.00 | 1 | |
U-37883A functions as a KIR by selectively binding to specific sites on potassium channels, leading to conformational changes that modulate ion conductance. Its unique structure facilitates strong interactions with channel proteins, enhancing the stability of the open state. The compound exhibits rapid kinetics, allowing for swift adjustments in channel activity in response to cellular signals, thereby influencing membrane potential and excitatory responses in various cellular environments. | ||||||
Terfenadine | 50679-08-8 | sc-208421A sc-208421B sc-208421 | 500 mg 1 g 5 g | $44.00 $71.00 $120.00 | ||
Terfenadine acts as a KIR by engaging with potassium ion channels through specific molecular interactions that alter channel dynamics. Its unique conformation promotes distinct binding affinities, resulting in altered gating mechanisms. The compound's interaction kinetics are characterized by a notable speed, enabling it to effectively modulate ion flow in response to physiological stimuli. This behavior contributes to the fine-tuning of cellular excitability and ion homeostasis. | ||||||