Molecular structure of U-37883A, CAS Number: 57568-80-6
U-37883A (CAS 57568-80-6)
See product citations (1)
Alternate Names:
PNU 37883 hydrochloride; N-Cyclohexyl-N′-tricyclo[3.3.1.13,7] dec-1-yl-4-morpholinecarboximidamide hydrochloride
Application:
U-37883A is a potent inhibitor of vascular smooth muscle KIR6 channels
CAS Number:
57568-80-6
Molecular Weight:
381.98
Molecular Formula:
C21H35N3O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
U-37883A is a potent inhibitor of vascular smooth muscle K-ATP (KIR6) channels. Useful biological tool in distinguishing between Kir6.1 and Kir6.2 chimeric protein functions as well as the different sulfonylurea-sensitive K+ channel subtypes. This product shows significant selectivity for K-ATP channels over KV and KIR channels in smooth muscle cells.
U-37883A (CAS 57568-80-6) References
- Inhibition of vascular K(ATP) channels by U-37883A: a comparison with cardiac and skeletal muscle. | Wellman, GC., et al. 1999. Br J Pharmacol. 128: 909-16. PMID: 10556925
- Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A. | Kovalev, H., et al. 2004. Br J Pharmacol. 141: 867-73. PMID: 14757705
- Multiple actions of U-37883A, an ATP-sensitive K+ channel blocker, on membrane currents in pig urethra. | Tomoda, T., et al. 2005. Eur J Pharmacol. 524: 1-10. PMID: 16242124
- Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels. | Teramoto, N. 2006. Cardiovasc Drug Rev. 24: 25-32. PMID: 16939631
- Diuretic activity of N'-disubstituted morpholinoguanidine analogs of U-37883A in rats and dogs. | Humphrey, SJ., et al. 1995. Methods Find Exp Clin Pharmacol. 17: 255-66. PMID: 7475512
- Functional receptors in Xenopus oocytes for U-37883A, a novel ATP-sensitive K+ channel blocker: comparison with rat insulinoma cells. | Guillemare, E., et al. 1994. Mol Pharmacol. 46: 139-45. PMID: 8058048
- Synergistic effects of glyburide and U-37883A, two structurally different vascular ATP-sensitive potassium channel antagonists. | Ohrnberger, CE., et al. 1993. J Pharmacol Exp Ther. 267: 25-30. PMID: 8229751
- 4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexylhydrochloride (U-37883A): pharmacological characterization of a novel antagonist of vascular ATP-sensitive K+ channel openers. | Meisheri, KD., et al. 1993. J Pharmacol Exp Ther. 266: 655-65. PMID: 8355199
- Guanidine derivative U-37883A, inhibits mitochondrial K+ uniport. | Szewczyk, A., et al. 1995. Pol J Pharmacol. 47: 339-44. PMID: 8616514
- Cardiovascular effects of the K-ATP channel blocker U-37883A and structurally related morpholinoguanidines. | Humphrey, SJ., et al. 1996. Methods Find Exp Clin Pharmacol. 18: 247-60. PMID: 8803957
- Effects of U-37883A, a vascular selective KATP+ channel antagonist, in the pulmonary and hindlimb circulation. | DeWitt, BJ., et al. 1996. Am J Physiol. 271: L924-31. PMID: 8997262
- U-37883A potently inhibits dopamine-modulated K+ channels on rat striatal neurons. | Lin, YJ., et al. 1998. Eur J Pharmacol. 352: 335-41. PMID: 9716371
- Interaction of the diuretics torasemide and U-37883A with the K(ATP) channel in rat isolated aorta. | Löffler-Walz, C. and Quast, U. 1998. Naunyn Schmiedebergs Arch Pharmacol. 358: 230-7. PMID: 9750009
Inhibitor of:
KIR.Activator of:
KIR6.1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U-37883A, 5 mg | sc-201001 | 5 mg | $81.00 | |||
U-37883A, 25 mg | sc-201001A | 25 mg | $385.00 |