U-37883A CAS: 57568-80-6
MF: C21H35N3O·HCl
MW: 381.98
A potent inhibitor of vascular smooth muscle KIR6 channels.

U-37883A (CAS 57568-80-6)

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Alternate Names: PNU 37883 hydrochloride; N-Cyclohexyl-N'-tricyclo[3.3.1.13,7] dec-1-yl-4-morpholinecarboximidamide hydrochloride
Application: U-37883A is a potent inhibitor of vascular smooth muscle KIR6 channels
CAS Number: 57568-80-6
Molecular Weight: 381.98
Molecular Formula: C21H35N3O·HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

U-37883A is a potent inhibitor of vascular smooth muscle K-ATP (KIR6) channels. Useful biological tool in distinguishing between Kir6.1 and Kir6.2 chimeric protein functions as well as the different sulfonylurea-sensitive K+ channel subtypes. This product shows significant selectivity for K-ATP channels over KV and KIR channels in smooth muscle cells.


References

1. Lin, Y.J., et al. 1998. Eur. J. Pharmacol. 352: 335-341. PMID: 9716371
2. Wellman, G.C., et al. 1999. Br. J. Pharmacol. 128: 909-916. PMID: 10556925
3. Kovalev, H., et al. 2004. Br. J. Pharmacol. 141: 867-873. PMID: 14757705
4. Teramoto, N. 2006. Cardiovasc Drug Rev. 24: 25-32. PMID: 16939631
5. Ploug, K.B., et al. 2008. Br. J. Pharmacol. 154: 72-81. PMID: 18332850

Physical State :
Solid
Solubility :
Soluble in water(5 mg/ml)
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
64392
SMILES :
C1CCC(CC1)N=C(NC23CC4CC(C2)CC(C4)C3)N5CCOCC5.Cl

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Certificate of Analysis

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U-37883A (CAS 57568-80-6)  Product Citations

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PMID: # 8616514  Szewczyk, A. et al. 1995 Jul-Aug. Pol J Pharmacol. 47: 339-344.

Citations 1 to 1 of 1 total
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