Glimepiride CAS: 93479-97-1
MF: C24H34N4O5S
MW: 490.62
A third generation sulfonylurea compound that induces the PI3K and Akt pathway,.

Glimepiride (CAS 93479-97-1)

Glimepiride | CAS 93479-97-1 is rated 5.0 out of 5 by 1.
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Alternate Names: Amaryl, Glista OD
Application: Glimepiride is a third generation sulfonylurea compound that induces the PI3K and Akt pathway,
CAS Number: 93479-97-1
Purity: ≥98%
Molecular Weight: 490.62
Molecular Formula: C24H34N4O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Glimepiride is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker.


References

1. Inukai, K., et al. 2005. Biochem. Biophys. Res. Commun. 328: 484-490. PMID: 15694373
2. Ma, P., et al. 2010. Metab. Clin. Exp. 59: 359-366. PMID: 19800638

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at room temperature
Melting Point :
212-215° C
Boiling Point :
750.37° C (Predicted)
Density :
1.30 g/cm3 (Predicted)
Refractive Index :
n20D 1.60
pK Values :
pKa: 5.1 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UX9363950
PubChem CID :
3476
Merck Index :
14: 4440
MDL Number :
MFCD00878417
SMILES :
CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC2CC[[email protected]](C)CC2)C1=O

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. This chemical is supplied as a white powder. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-16
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Rated 5 out of 5 by from Ma et al Ma et al. (PubMed ID 19800638) found that Glimepiride induced rat osteoblast proliferation and differentiation via PI3-kinase/Akt pathway activation. -SCBT Publication Review
Date published: 2015-04-13
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