Molecular structure of Glimepiride, CAS Number: 93479-97-1
Glimepiride (CAS 93479-97-1)
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Alternate Names:
Amaryl, Glista OD
Application:
Glimepiride is a third generation sulfonylurea compound that induces the PI3K and Akt pathway,
CAS Number:
93479-97-1
Purity:
≥98%
Molecular Weight:
490.62
Molecular Formula:
C24H34N4O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Glimepiride is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor gamma activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker.
Glimepiride (CAS 93479-97-1) References
- Glimepiride enhances intrinsic peroxisome proliferator-activated receptor-gamma activity in 3T3-L1 adipocytes. | Inukai, K., et al. 2005. Biochem Biophys Res Commun. 328: 484-90. PMID: 15694373
- Glimepiride induces proliferation and differentiation of rat osteoblasts via the PI3-kinase/Akt pathway. | Ma, P., et al. 2010. Metabolism. 59: 359-66. PMID: 19800638
- Glimepiride treatment facilitates ischemic preconditioning in the diabetic heart. | Hausenloy, DJ., et al. 2013. J Cardiovasc Pharmacol Ther. 18: 263-9. PMID: 23263382
- Glimepiride reduces CD14 expression and cytokine secretion from macrophages. | Ingham, V., et al. 2014. J Neuroinflammation. 11: 115. PMID: 24952384
- Glimepiride promotes osteogenic differentiation in rat osteoblasts via the PI3K/Akt/eNOS pathway in a high glucose microenvironment. | Ma, P., et al. 2014. PLoS One. 9: e112243. PMID: 25391146
- Glimepiride protects neurons against amyloid-β-induced synapse damage. | Osborne, C., et al. 2016. Neuropharmacology. 101: 225-36. PMID: 26432105
- Pharmacokinetics and pharmacodynamics of glimepiride polymorphs. | Viana, ALM., et al. 2018. Int J Pharm. 553: 272-280. PMID: 30359686
- Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat. | Zhou, X., et al. 2019. Br J Pharmacol. 176: 478-490. PMID: 30471094
- Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice. | Niedowicz, DM., et al. 2018. J Diabetes Res. 2018: 1251345. PMID: 30510962
- Effect of glimepiride on the pharmacokinetics of teneligliptin in healthy Korean subjects. | Park, JW., et al. 2019. J Clin Pharm Ther. 44: 720-725. PMID: 31094010
- A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties. | Bian, X., et al. 2019. Molecules. 24: PMID: 31640214
- Glimepiride and glibenclamide have comparable efficacy in treating acute ischemic stroke in mice. | Wang, X., et al. 2020. Neuropharmacology. 162: 107845. PMID: 31704276
- Pharmacogenetic-guided glimepiride therapy in type-2 diabetes mellitus: a cost-effectiveness study. | Fokoun, C., et al. 2021. Pharmacogenomics J. 21: 559-565. PMID: 33731883
- Design and evaluation of glimepiride hydrogel for transdermal delivery. | Li, H., et al. 2022. Drug Dev Ind Pharm. 48: 397-405. PMID: 36048002
- Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases (PI3K)/protein kinase (AKT) pathways. | ElMahdy, MK., et al. 2022. Life Sci. 311: 121184. PMID: 36375572
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KIR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Glimepiride, 500 mg | sc-203058 | 500 mg | $101.00 | |||
Glimepiride, 1 g | sc-203058A | 1 g | $148.00 |