9930039A11Rik Inhibitors

Ring finger protein 222," encoded by the gene "21618," is a member of the RING (Really Interesting New Gene) family of proteins, which are characterized by the presence of a RING finger domain. This domain typically consists of a C3HC4 amino acid motif that binds two zinc ions, and it is integral to the protein's role in mediating a variety of cellular processes.The gene "21618" serves as a unique identifier within a genomic database, pinpointing the specific genetic sequence that codes for the ring finger protein 222. This protein, through its RING finger domain, is often involved in ubiquitination, a post-translational modification process where ubiquitin molecules are attached to substrate proteins. Ubiquitination can signal for protein degradation via the proteasome, alter protein function, or affect protein localization within the cell.

As with other RING finger proteins, ring finger protein 222 may act as an E3 ubiquitin ligase, which plays a crucial role in the transfer of ubiquitin from the E2 conjugating enzyme to specific substrate proteins. The specificity of the ubiquitination process is largely determined by the E3 ligase, thus ring finger protein 222 may be involved in targeting specific proteins for ubiquitination, influencing various cellular pathways including cell cycle regulation, DNA repair, signal transduction, and transcriptional regulation.The detailed functions of ring finger protein 222 are likely to be context-dependent, varying with cell type, developmental stage, and external stimuli. Studying this protein's interactions and ubiquitination targets could provide valuable insights into the intricate regulatory networks within cells. Disruptions in the function of RING finger proteins like ring finger protein 222 are associated with a range of diseases, including cancer, neurodegenerative disorders, and immune system dysfunctions, due to their pivotal roles in controlling protein homeostasis and signaling pathways.