53BP2 Inhibitors

53BP2 Inhibitors encompass compounds that indirectly affect the function of 53BP2 by influencing pathways associated with apoptosis, DNA damage response, and p53 signaling. These inhibitors do not directly target 53BP2 but modulate the cellular environment and pathways in which 53BP2 is involved. Compounds such as Nutlin-3, Pifithrin-α, MDM2 Inhibitors, and RITA target the p53 signaling pathway. Since 53BP2 interacts with p53 and functions in p53-mediated pathways, influencing p53 activity can indirectly affect 53BP2's role. For instance, Nutlin-3 disrupts the p53-MDM2 interaction, altering the functional context in which 53BP2 operates.

Other inhibitors, including DNA damaging agents like Cisplatin, Doxorubicin, Etoposide, Camptothecin, 5-Fluorouracil, and Vinblastine, activate p53-related pathways. These compounds, by inducing DNA damage, can influence 53BP2's function in the DNA damage response and apoptosis. Additionally, compounds like KU-55933 and Tenovin-6, which target ATM and SIRT1/2 respectively, can also indirectly modulate 53BP2's activity through their impact on DNA damage response and cell cycle regulation pathways.